小鼠髓系白血病发展过程中变化的电子自旋共振研究。I. 顺磁性金属离子。
Electron spin resonance study of changes during the development of a mouse myeloid leukaemia. I. Paramagnetic metal ions.
作者信息
Dodd N J
出版信息
Br J Cancer. 1975 Jul;32(1):108-20. doi: 10.1038/bjc.1975.137.
Abstract
The blood, spleen and liver of mice were examined by means of electron spin resonance (e.s.r.), throughout the course of myeloid leukaemia induced by intravenous injection of leukaemic spleen cells. In blood, marked increases in the concentrations of iron transferrin and ceruloplasmin occurred within the first 3 days after injection. In the spleen, changes in the concentrations of paramagnetic copper and iron complexes were detectable by about the 5th day, before any measurable splenic enlargement, whilst in the liver changes were detectable by about the 8th day. The changes occurring in blood, spleen and liver during the development of leukaemia appear to be related and they are discussed in terms of iron transport.
摘要
在通过静脉注射白血病脾细胞诱导小鼠发生髓性白血病的整个过程中，采用电子自旋共振（e.s.r.）技术对小鼠的血液、脾脏和肝脏进行了检查。在血液中，注射后第1个3天内转铁蛋白和铜蓝蛋白的浓度显著增加。在脾脏中，大约在第5天可检测到顺磁性铜和铁络合物浓度的变化，此时脾脏尚无任何可测量的肿大，而在肝脏中，大约在第8天可检测到变化。白血病发展过程中血液、脾脏和肝脏中发生的变化似乎是相关的，并且从铁转运的角度对这些变化进行了讨论。
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