小鼠髓性白血病发育过程中变化的电子自旋共振研究。II. 抗坏血酸自由基。

Electron spin resonance study of changes during the development of a mouse myeloid leukaemia. II. The ascorbyl radical.

作者信息

Dodd N J, Giron-Conland J M

出版信息

Br J Cancer. 1975 Oct;32(4):451-5. doi: 10.1038/bjc.1975.246.

DOI:10.1038/bjc.1975.246

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2024765/

Abstract

The ascorbyl radical concentration has been observed, by means of electron spin resonance spectroscopy, in the blood, spleen and liver of RF/J female mice throughout the development of a myeloid leukaemia. Changes in the concentration of the radical were detectable from an early stage in the disease and did not appear to be directly due to the leukaemic cells but could possibly be due to a reaction against them. Changes in the concentration of the paramagnetic metal ions during the leukaemia have been reported previously and it was found that changes in some of these species correlated with changes in the ascorbyl radical concentration.

摘要

通过电子自旋共振光谱法，在RF/J雌性小鼠患髓性白血病的整个病程中，对其血液、脾脏和肝脏中的抗坏血酸自由基浓度进行了观察。在疾病早期即可检测到自由基浓度的变化，这些变化似乎并非直接由白血病细胞引起，而是可能由于机体对白血病细胞的反应所致。此前已有关于白血病期间顺磁性金属离子浓度变化的报道，并且发现其中一些金属离子浓度的变化与抗坏血酸自由基浓度的变化相关。

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Electron spin resonance study of changes during the development of a mouse myeloid leukaemia. I. Paramagnetic metal ions.

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