Ang Tiing Leong, Fock Kwong Ming, Teo Eng Kiong, Chua Tju Siang, Tan Jessica
Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore 529889, Singapore.
J Gastroenterol. 2006 Aug;41(8):765-71. doi: 10.1007/s00535-006-1849-3.
This study audited the clinical outcome of a cohort of patients with choledocholithiasis treated with long-term biliary stenting in order to determine the feasibility of this practice.
Over 2 years, 83 patients with symptomatic choledocholithiasis were treated with long-term stenting because they either refused further treatments or were medically unfit for further procedures after the initial endoscopic retrograde cholangiopancreatography (ERCP). Recurrence of clinical events, need for stent change, morbidity, and mortality were analyzed. As a secondary analysis, published data on long-term biliary stenting were reviewed.
ERCP and biliary stenting were successful in all cases with no complications. The mean follow-up was 19 months (1-103 months). The median number of ERCPs performed was 1 (1-4). The mean duration of stent patency was 12.4 months (1-54.8 months). A total of 28 clinical events (cholangitis, 71%) occurred in 24 patients during follow-up, for a late complication rate of 33.7%. ERCP was repeated and the stents changed on 15 occasions in 11 asymptomatic patients with abnormal liver function tests detected on routine follow-up. No biliary-related mortality occurred. Review of published data revealed a mean late complication rate of 22.4% (0%-64%), a biliary-related mortality rate of 3.5% (0%-21.1%), and a nonbiliary-related mortality rate of 20.8% (0%-60.3%).
Long-term biliary stenting is a feasible option for patients who decline or are medically unfit for further elective endoscopic or surgical procedures. Close follow-up is mandatory to detect and treat late complications.
本研究对一组接受长期胆道支架置入术治疗的胆总管结石患者的临床结局进行了审计,以确定这种治疗方法的可行性。
在2年多的时间里,83例有症状的胆总管结石患者接受了长期支架置入术,因为他们要么拒绝进一步治疗,要么在初次内镜逆行胰胆管造影术(ERCP)后因身体状况不适合进一步手术。分析了临床事件的复发情况、支架更换的必要性、发病率和死亡率。作为次要分析,对已发表的关于长期胆道支架置入术的数据进行了回顾。
所有病例的ERCP和胆道支架置入术均成功,无并发症。平均随访时间为19个月(1 - 103个月)。ERCP的中位施行次数为1次(1 - 4次)。支架通畅的平均持续时间为12.4个月(1 - 54.8个月)。随访期间,24例患者共发生28次临床事件(胆管炎,71%),晚期并发症发生率为33.7%。11例无症状患者在常规随访中肝功能检查异常,ERCP重复进行,支架更换15次。未发生与胆道相关的死亡。对已发表数据的回顾显示,平均晚期并发症发生率为22.4%(0% - 64%),与胆道相关的死亡率为3.5%(0% - 21.1%),与非胆道相关的死亡率为20.8%(0% - 60.3%)。
对于拒绝或身体状况不适合进一步选择性内镜或外科手术的患者,长期胆道支架置入术是一种可行的选择。必须密切随访以检测和治疗晚期并发症。