Li Yibin, Xu Liang, Jonas Jost B, Yang Hua, Ma Yingnan, Li Jianjun
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Capital University of Medical Science, Beijing, China.
Am J Ophthalmol. 2006 Nov;142(5):788-93. doi: 10.1016/j.ajo.2006.06.001. Epub 2006 Sep 20.
To evaluate the prevalence of age-related maculopathy (ARM) in adult Chinese living in rural or urban regions of mainland China.
Population-based prevalence study.
The study included 4439 subjects (aged 40 or more years) out of 5324 subjects invited to participate (response rate 83.4%). It was held in rural and urban regions of Greater Beijing. The participants underwent a detailed ophthalmic examination including fundus photography. All fundus photographs were graded by the Wisconsin Age-Related Maculopathy Grading System.
Fundus photographs were available for 4376 (98.6%) subjects. Early ARM was present in 122 (1.4%) of 8655 (95% confidence interval [CI] 1.16% to 1.66%) eyes or 63 (1.4%) of 4376 (95% CI 1.09% to 1.79%) subjects, late ARM in 12 (0.14%) of 8655 (95% CI 0.06% to 0.22%) eyes or seven (0.2%) of 4376 (95% CI 0.04% to 0.28%) subjects, and exudative ARM as part of late ARM in seven (0.1%) of 8655 (95% CI 0.02% to 0.14%) eyes or six (0.1%) of 4376 (95% CI 0.03% to 0.25%) subjects. The prevalence of early ARM, late ARM, and exudative ARM, respectively, increased from 0.61%, 0.07%, and 0.07% in the 40-to-44-year age group, to 1.66%, 0.26%, and 0.26% in the 55-to-59-year group, and to 2.99%, 0.90%, and 0.60% in the group aged 75 years and older. ARM was causative for visual impairment (best-corrected visual acuity in the better eye, <20/60 and > or =20/400) or blindness (visual acuity <20/400) in one subject (0.023%).
Visual impairment due to ARM was relatively uncommon in the adult Chinese population in rural and urban regions.
评估中国大陆农村及城市成年居民年龄相关性黄斑病变（ARM）的患病率。
基于人群的患病率研究。
在受邀参与的5324名受试者中，有4439名（年龄40岁及以上）参与了研究（应答率83.4%）。研究在北京大都市区的农村和城市地区开展。参与者接受了包括眼底照相在内的详细眼科检查。所有眼底照片均按照威斯康星年龄相关性黄斑病变分级系统进行分级。
4376名（98.6%）受试者有眼底照片。在8655只眼中，122只（1.4%）有早期ARM（95%可信区间[CI] 1.16%至1.66%），在4376名受试者中，63名（1.4%）有早期ARM（95% CI 1.09%至1.79%）；在8655只眼中，12只（0.14%）有晚期ARM（95% CI 0.06%至0.22%），在4376名受试者中，7名（0.2%）有晚期ARM（95% CI 0.04%至0.28%）；在8655只眼中，7只（0.1%）有作为晚期ARM一部分的渗出性ARM（95% CI 0.02%至0.14%），在4376名受试者中，6名（0.1%）有渗出性ARM（95% CI 0.03%至0.25%）。早期ARM、晚期ARM和渗出性ARM的患病率分别从40至44岁年龄组的0.61%、0.07%和0.07%，增加至55至59岁组的1.66%、0.26%和0.26%，以及75岁及以上组的2.99%、0.90%和0.60%。有一名受试者（0.023%）的ARM导致了视力损害（较好眼最佳矫正视力<20/60且>或=20/400）或失明（视力<20/400）。
在中国大陆农村及城市成年人群中，由ARM导致的视力损害相对不常见。
