Miller Benjamin F, Hansen Mette, Olesen Jens L, Schwarz Peter, Babraj John A, Smith Kenneth, Rennie Michael J, Kjaer Michael
Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, Denmark.
J Appl Physiol (1985). 2007 Feb;102(2):541-6. doi: 10.1152/japplphysiol.00797.2006. Epub 2006 Sep 21.
In general, there is a higher incidence of musculoskeletal injuries during physical activity in women than in men. We hypothesized that in women rates of tendon collagen synthesis would be lower than in men at rest and after exercise, especially in the later luteal phase when estrogen and progesterone concentrations are higher than the early follicular phase. We studied tendon collagen fractional synthesis rate (FSR) in 15 young, healthy female subjects in either the early follicular (n = 8) or the late luteal phase (n = 7) 72 h after an acute bout of one-legged exercise (60 min kicking at 67% workload maximum) (72 h) and compared the results with those previously obtained for men. Samples were taken from the patellar tendon in both the exercised and rested legs to determine collagen FSR by the incorporation of [15N]proline into tendon collagen hydroxyproline. There was no effect of menstrual phase on tendon collagen synthesis either at rest or after exercise. However, there was a significant difference between women and men at rest (women = 0.025 +/- 0.002%/h, men = 0.045 +/- 0.008%/h; P < 0.05) and 72 h after exercise (women = 0.027 +/- 0.005%/h; men = 0.058 +/- 0.008%/h). Furthermore, rest and 72-h tendon collagen synthesis were not different in women, whereas in men tendon collagen synthesis remained significantly elevated 72 h after exercise. It is concluded that both in the resting state and after exercise, tendon collagen FSR is lower in women than in men, which may contribute to a lower rate of tissue repair after exercise.
一般来说，女性在体育活动中肌肉骨骼损伤的发生率高于男性。我们推测，女性肌腱胶原蛋白合成率在静息状态和运动后低于男性，尤其是在黄体期后期，此时雌激素和孕激素浓度高于卵泡期早期。我们研究了15名年轻健康女性受试者在卵泡期早期（n = 8）或黄体期后期（n = 7）进行一次急性单腿运动（60分钟，以67%最大工作量踢腿）72小时后肌腱胶原蛋白分数合成率（FSR），并将结果与之前对男性的研究结果进行比较。从运动腿和静息腿的髌腱取样，通过将[15N]脯氨酸掺入肌腱胶原蛋白羟脯氨酸中来测定胶原蛋白FSR。月经周期对静息状态或运动后肌腱胶原蛋白合成均无影响。然而，女性和男性在静息状态下（女性 = 0.025 +/- 0.002%/小时，男性 = 0.045 +/- 0.008%/小时；P < 0.05）以及运动72小时后（女性 = 0.027 +/- 0.005%/小时；男性 = 0.058 +/- 0.008%/小时）存在显著差异。此外，女性静息状态和运动72小时后的肌腱胶原蛋白合成没有差异，而男性运动72小时后肌腱胶原蛋白合成仍显著升高。结论是，无论在静息状态还是运动后，女性肌腱胶原蛋白FSR均低于男性，这可能导致运动后组织修复率较低。
