Hoeller Daniela, Hecker Christina-Maria, Dikic Ivan
Institute of Biochemistry II, Goethe University School of Medicine, University Hospital, Building 75, Theodour-Stern-Kai 7, D-60590 Frankfurt, Germany.
Nat Rev Cancer. 2006 Oct;6(10):776-88. doi: 10.1038/nrc1994.
Ubiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many cellular functions, such as cell proliferation, apoptosis, the cell cycle and DNA repair. It is becoming apparent that the deregulation of ubiquitin pathways results in the development of human diseases, including many types of tumours. Here we summarize the common principles and specific features of ubiquitin and Ubls in the regulation of cancer-relevant pathways, and discuss new strategies to target ubiquitin signalling in drug discovery.
泛素和类泛素蛋白（Ubls）是控制许多细胞功能的信号信使，如细胞增殖、凋亡、细胞周期和DNA修复。越来越明显的是，泛素途径的失调会导致人类疾病的发生，包括多种类型的肿瘤。在这里，我们总结了泛素和Ubls在调节癌症相关途径中的共同原则和特定特征，并讨论了在药物发现中靶向泛素信号的新策略。
