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[健康献血者血液中甲型和乙型流感病毒抗原的检测]

[The detection of the antigens of influenza viruses A and B in the blood of healthy donors].

作者信息

Rovnova Z I, Isaeva E I

出版信息

Vopr Virusol. 1990 May-Jun;35(3):190-3.

PMID:1699358
Abstract

Blood clots and sera were obtained from donors at a Moscow city transfusion clinic during 1984-1988 and tested by indirect solid-phase enzyme immunoassay with original test-sera to hemagglutinating antigens of influenza A (H1 and H3) and B viruses. Examinations of 1714 blood samples demonstrated hemagglutinating antigens of different specificity (from 0.8% to 35%), the detection rate of one or another antigen correlating with the epidemic activity of influenza virus serovariants A and B. The virus-specific antigens, however, were almost regularly detected in the blood of healthy subjects in the interepidemic seasons as well. The highest number of positive results was observed in tests with blood clot or serum. The results indicate the principal capacity of influenza virus to persist in apparently normal subjects.

摘要

1984年至1988年期间,从莫斯科市一家输血诊所的献血者那里获取了血凝块和血清,并用针对甲型(H1和H3)和乙型流感病毒血凝素抗原的原始检测血清,通过间接固相酶免疫测定法进行检测。对1714份血样的检测显示出不同特异性的血凝素抗原(从0.8%到35%),一种或另一种抗原的检出率与甲型和乙型流感病毒血清变种的流行活动相关。然而,在流行间歇期,健康受试者的血液中也几乎经常检测到病毒特异性抗原。在对血凝块或血清的检测中观察到的阳性结果数量最多。结果表明流感病毒在看似正常的个体中持续存在的主要能力。

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