Isaeva E I, Rovnova Z I, Poliakova T G, Viazov S O
Vopr Virusol. 1993 Jul-Aug;38(4):146-9.
Antigens of influenza A and B viruses in the peripheral blood lymphocytes of normal human subjects are found regularly both in epidemic and interepidemic periods. The level of detection of viral proteins in lymphocytes varies widely and correlates with the epidemic activity of the viruses. Influenza virus antigens were found several months before a rise in the incidence of the disease, the per cent ratio of the identified antigens correlating with the pattern of antigen detection in nasopharyngeal washings during an epidemic outbreak. Most frequently, the antigen found in lymphocytes was that of the main etiological agent of a definite epidemic; less frequently the hemagglutinin of the virus accompanying the one dominant in a given epidemic was found.
在正常人类受试者的外周血淋巴细胞中，甲型和乙型流感病毒抗原在流行期和非流行期均能经常被检测到。淋巴细胞中病毒蛋白的检测水平差异很大，且与病毒的流行活动相关。在疾病发病率上升前数月就能检测到流感病毒抗原，所鉴定抗原的百分比与流行暴发期间鼻咽冲洗液中抗原检测模式相关。最常见的情况是，淋巴细胞中发现的抗原是某一特定流行的主要病原体的抗原；较少见的是，发现了伴随特定流行中占主导地位的病毒的血凝素。
