Alawi Faizan, Robinson Brian T, Carrasco Lee
Department of Dermatology, Section of Dermatopathology, Division of Oral and Maxillofacial Pathology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Oct;102(4):506-12. doi: 10.1016/j.tripleo.2005.10.071. Epub 2006 Mar 20.
Rosai-Dorfman disease (RDD) is a rare, non-neoplastic histiocytosis most commonly characterized by painless, massive cervical lymphadenopathy. Over half of all patients with lymph node involvement also demonstrate extranodal disease, with most affected individuals exhibiting lesions within the region of the head and neck. Oral manifestations of RDD are extremely rare, and almost always identified in association with nodal or other extranodal disease. However, rare examples of extranodal RDD, including oral RDD, without clinical or radiographic evidence of concomitant lymph node involvement, have also been described. We report a rare case of solitary, extranodal RDD arising within the mandible in a pregnant woman. To our knowledge, this case represents only the fourth documented example of solitary oral RDD. A review of the clinical and histopathologic features associated with RDD is also presented.
罗萨伊-多夫曼病（RDD）是一种罕见的非肿瘤性组织细胞增生症，最常见的特征是无痛性、巨大的颈部淋巴结病。所有有淋巴结受累的患者中，超过一半还表现为结外病变，大多数受累个体在头颈部区域出现病变。RDD的口腔表现极为罕见，几乎总是与淋巴结或其他结外病变相关。然而，也有罕见的结外RDD病例报道，包括口腔RDD，无伴随淋巴结受累的临床或影像学证据。我们报告了一例罕见的孤立性结外RDD发生于一名孕妇下颌骨的病例。据我们所知，该病例是孤立性口腔RDD的第四例文献记载病例。本文还对与RDD相关的临床和组织病理学特征进行了综述。
