希腊一家儿科医院中OXA-58阳性耐碳青霉烯鲍曼不动杆菌菌株的医院内传播。
Nosocomial spread of OXA-58-positive carbapenem-resistant Acinetobacter baumannii isolates in a paediatric hospital in Greece.
作者信息
Poirel L, Lebessi E, Héritier C, Patsoura A, Foustoukou M, Nordmann P
机构信息
Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, France.
出版信息
Clin Microbiol Infect. 2006 Nov;12(11):1138-41. doi: 10.1111/j.1469-0691.2006.01537.x.
Twelve non-repetitive Acinetobacter baumannii isolates producing the carbapenem-hydrolysing oxacillinase OXA-58 were recovered from patients in the same paediatric hospital in Athens, Greece, between November 2003 and May 2005. All isolates were clonally related, but the bla(OXA-58) gene was not always plasmid-located and there were variations in the DNA sequences surrounding the OXA-58 gene in different isolates. This study emphasises the importance of the bla(OXA-58) carbapenemase gene in conferring carbapenem resistance among A. baumannii isolates in Greece.
2003年11月至2005年5月期间，从希腊雅典同一家儿科医院的患者中分离出12株产生碳青霉烯水解型苯唑西林酶OXA-58的非重复性鲍曼不动杆菌。所有分离株均为克隆相关，但bla(OXA-58)基因并非总是位于质粒上，且不同分离株中OXA-58基因周围的DNA序列存在差异。本研究强调了bla(OXA-58)碳青霉烯酶基因在希腊鲍曼不动杆菌分离株中赋予碳青霉烯耐药性的重要性。
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