Stoeva T, Higgins P G, Bojkova K, Seifert H
Department of Microbiology and Virology, Medical University, Varna, Bulgaria.
Clin Microbiol Infect. 2008 Jul;14(7):723-7. doi: 10.1111/j.1469-0691.2008.02018.x.
From October 1999 to September 2006, 29 carbapenem-resistant isolates of Acinetobacter baumannii were collected consecutively from patients hospitalized in different wards of the University Hospital in Pleven, Bulgaria. The bla(OXA-23) gene, associated with the upstream-located ISAba1, was identified as the mechanism responsible for carbapenem resistance in all isolates. The isolates belonged to two different clonal groups, indicating a sustained hospital outbreak. This study demonstrates both the epidemic potential of carbapenem-resistant A. baumannii and its longevity in the hospital environment.
1999年10月至2006年9月期间，从保加利亚普列文大学医院不同病房住院的患者中连续收集了29株耐碳青霉烯鲍曼不动杆菌分离株。与上游定位的ISAba1相关的bla(OXA - 23)基因被确定为所有分离株中耐碳青霉烯的机制。这些分离株属于两个不同的克隆组，表明医院内持续爆发。本研究证明了耐碳青霉烯鲍曼不动杆菌的流行潜力及其在医院环境中的持久性。
