Gertler Arieh
The Institute of Biochemistry, Food Science, and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel.
Trends Endocrinol Metab. 2006 Nov;17(9):372-8. doi: 10.1016/j.tem.2006.09.006. Epub 2006 Sep 28.
Leptin is a pleotropic hormone that acts both centrally and peripherally. Whereas leptin exhibits positive effects on several physiological functions, such as regulation of energy metabolism, reproductive function and immune responses, negative actions, such as enhancement of undesired immune responses in autoimmune diseases, tumorigenesis, elevated blood pressure and cardiovascular pathologies, have also been documented. The recent development of leptin muteins with antagonistic properties and other proteins that block leptin activity opens up new possibilities for their use in research and, eventually, therapy.
瘦素是一种具有多效性的激素，在中枢和外周均发挥作用。虽然瘦素对多种生理功能具有积极作用，如调节能量代谢、生殖功能和免疫反应，但也有文献记载其存在消极作用，如在自身免疫性疾病中增强不良免疫反应、肿瘤发生、血压升高和心血管病变。最近具有拮抗特性的瘦素突变体及其他阻断瘦素活性的蛋白质的研发，为其在研究及最终治疗中的应用开辟了新的可能性。
