Nomura Mizuho, Tanaka Masaru, Nunomura Maki, Izumi Miki, Oryu Fuyuki
Departments of Dermatology, Tokyo Woman's Medical University Medical Center East, 2-1-10 Nishi-Ogu, Arakawa-ku, Tokyo 116-8567, Japan.
Dermatol Res Pract. 2010;2010. doi: 10.1155/2010/140486. Epub 2010 Jul 27.
A 77-year-old Japanese woman presented a dome-shaped pinkish nodule on the scalp. Dermoscopy demonstrated yellowish homogeneous ovoid areas with translucent whitish veil and arborizing vessels. No association with Muir-Torre syndrome was found. Histopathology revealed a smooth-bordered neoplasm in the dermis with partial connection to the epidermis. The tumor was composed mainly of germinative cells. The tumor focally showed a typical "rippled pattern". There were only a few vacuolated cells suggesting sebaceous differentiation. These cells were highlighted with adipophilin antibody. No nuclear atypia or mitotic figures were observed. We regarded the neoplasm as sebaceoma. Dermoscopy demonstrated clearly visualized yellowish homogeneous ovoid areas. This feature usually corresponds to dermal conglomerations of the cells with sebaceous differentiation. However, this case histopathologically showed only limited area with sebaceous differentiation. We presented a case of rippled-pattern sebaceoma and described its dermoscopic features. This was the first report referring to the dermoscopic features of sebaceoma.
一名77岁的日本女性头皮上出现了一个圆顶状粉红色结节。皮肤镜检查显示有淡黄色均匀卵圆形区域，伴有半透明白色薄纱和树枝状血管。未发现与穆尔-托里综合征相关。组织病理学显示真皮内有边界光滑的肿瘤，与表皮部分相连。肿瘤主要由生发细胞组成。肿瘤局部呈现典型的“波纹状模式”。仅有少数空泡化细胞提示皮脂腺分化。这些细胞用亲脂素抗体染色后更为明显。未观察到核异型性或有丝分裂象。我们将该肿瘤视为皮脂腺瘤。皮肤镜检查清晰显示淡黄色均匀卵圆形区域。此特征通常对应于具有皮脂腺分化的细胞在真皮内的聚集。然而，该病例组织病理学显示仅有有限区域有皮脂腺分化。我们报告了一例具有波纹状模式的皮脂腺瘤病例，并描述了其皮肤镜特征。这是首次提及皮脂腺瘤皮肤镜特征的报告。
