Ayyanar Pavithra, Sahu Ajit, Tripathy Sagar R, Muduly Dillip K
From the Department of Pathology and Lab Medicine, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India.
Department of Surgical Oncology, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India.
Indian J Dermatol. 2024 Sep-Oct;69(5):423. doi: 10.4103/ijd.ijd_280_24. Epub 2024 Oct 29.
The rippled pattern of basal cell carcinoma (BCC) is a very uncommon variant and poses a diagnostic challenge. A 52-year-old male presented with an ulcerated lesion over the scalp for 8 years. The wedge biopsy of the lesion showed an infiltrating tumour in the upper dermis and mid-dermis with focal attachment with the epidermis. The tumour was arranged in a rippled pattern. The tumour cells were monomorphic with a round to oval nucleus, arranged parallelly with fine chromatin and inconspicuous nucleoli. Brisk mitosis, apoptotic bodies, and necrosis were noted. Immunohistochemically, the tumour cells were positive for p63; focally positive for androgen receptor, Bcl-2, and CD10; and negative for epithelial membrane antigen and CK20. We report this rare case of BCC because of its peculiar pattern, discuss the differential diagnoses, and review the clinicopathological features of reported cases.
基底细胞癌（BCC）的波纹状模式是一种非常罕见的变体，对诊断构成挑战。一名52岁男性头皮出现溃疡性病变8年。病变的楔形活检显示真皮上部和中部有浸润性肿瘤，与表皮有局灶性附着。肿瘤呈波纹状排列。肿瘤细胞单一形态，核圆形至椭圆形，平行排列，染色质细，核仁不明显。可见活跃的有丝分裂、凋亡小体和坏死。免疫组化显示，肿瘤细胞p63阳性；雄激素受体、Bcl-2和CD10局灶性阳性；上皮膜抗原和CK20阴性。我们报告这例罕见的基底细胞癌病例，因其独特的模式，讨论鉴别诊断，并回顾已报道病例的临床病理特征。
