Wjst Matthias
Pediatr Allergy Immunol. 2006 Nov;17(7):477-83. doi: 10.1111/j.1399-3038.2006.00456.x.
Oral vitamin D supplementation has been introduced into modern medicine to prevent rickets without the knowledge that this may have profound immunological consequences. The main vitamin D metabolite calcitriol suppresses dendritic cell maturation and consecutive Th(1) cell development, which has independently described as a key mechanism of allergy development. Animal studies and epidemiological surveys now provide a first link of early vitamin D supplementation and later allergy where several vitamin D regulated genes seem to be involved. A randomized clinical trial of vitamin D supplementation could be a further step to follow up the vitamin hypothesis.
口服补充维生素D已被引入现代医学以预防佝偻病，但当时并不知晓这可能会产生深远的免疫学后果。主要的维生素D代谢产物骨化三醇会抑制树突状细胞成熟以及后续的Th(1)细胞发育，这一过程已被独立描述为过敏发展的关键机制。动物研究和流行病学调查如今首次揭示了早期补充维生素D与后期过敏之间的联系，其中似乎涉及多个受维生素D调节的基因。补充维生素D的随机临床试验可能是进一步验证维生素假说的下一步举措。
