Guowei Ding, Adriane Kamulegeya, Chen Xingzai, Jie Chen, Yinfeng Liu
Tongji University Hospital, 50 Chifeng Road, 200092 Shanghai, PR China.
Int J Pharm. 2007 Jan 2;328(1):78-85. doi: 10.1016/j.ijpharm.2006.07.042. Epub 2006 Aug 4.
To synthesize and characterize a magnetic micromolecular delivery system based on PVP hydrogel with polyvinyl alcohol (PVA) as the crosslinker.
The microparticles were successfully prepared using 25 kGy Co-60 gamma-ray irradiation and characterized. Biocompatibility, in vitro and in vivo drug release tests were carried out.
Bleomycin was quantitatively released with in slightly over 8 h (hours) from the nanospheres containing 1mg bleomycin while the time was longer for those containing 5 mg. On the other hand free bleomycin quantitatively passed through the dialysis baffle with in only 3.5 h. For both 5 and 1 mg of bound bleomycin, it took up to 2 h to reach peak concentration compared to 30 min for the free drug.
The PVP hydrogel magnetic nanospheres exhibited passive drug release that could be exploited to enhance therapeutic efficacy. The present results indicate that PVP hydrogel based magnetic nanospheres have potential as drug carriers in magnetic guided chemotherapeutic drug delivery.
合成并表征一种以聚乙烯醇（PVA）为交联剂的基于聚乙烯吡咯烷酮（PVP）水凝胶的磁性微分子递送系统。
使用25 kGy的钴-60γ射线辐照成功制备了微粒并进行了表征。进行了生物相容性、体外和体内药物释放测试。
含1mg博来霉素的纳米球在略超过8小时内博来霉素定量释放，而含5mg博来霉素的纳米球释放时间更长。另一方面，游离博来霉素仅在3.5小时内定量通过透析膜。对于5mg和1mg结合的博来霉素，达到峰值浓度需要2小时，而游离药物仅需30分钟。
PVP水凝胶磁性纳米球表现出被动药物释放，可用于提高治疗效果。目前的结果表明，基于PVP水凝胶的磁性纳米球在磁性引导化疗药物递送中具有作为药物载体的潜力。
