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本文引用的文献

1
Prevotella intermedia lipopolysaccharide stimulates release of nitric oxide by inducing expression of inducible nitric oxide synthase.中间普氏菌脂多糖通过诱导诱导型一氧化氮合酶的表达刺激一氧化氮的释放。
J Periodontal Res. 2004 Dec;39(6):424-31. doi: 10.1111/j.1600-0765.2004.00757.x.
2
NO and angiogenesis.一氧化氮与血管生成
Atheroscler Suppl. 2003 Dec;4(4):53-60. doi: 10.1016/s1567-5688(03)00034-5.
3
Mice lacking inducible nitric oxide synthase demonstrate impaired killing of Porphyromonas gingivalis.缺乏诱导型一氧化氮合酶的小鼠对牙龈卟啉单胞菌的杀伤能力受损。
Infect Immun. 2003 Sep;71(9):4917-24. doi: 10.1128/IAI.71.9.4917-4924.2003.
4
Possible involvement of nitric oxide in the progression of diabetic retinopathy.一氧化氮可能参与糖尿病视网膜病变的进展。
Ophthalmologica. 2003 Sep-Oct;217(5):342-6. doi: 10.1159/000071349.
5
Nitric oxide synthase I mediates osteoclast activity in vitro and in vivo.一氧化氮合酶I在体外和体内介导破骨细胞活性。
J Cell Biochem. 2003 Jun 1;89(3):613-21. doi: 10.1002/jcb.10527.
6
Nitric oxide and vascular endothelial growth factor concentrations are increased but not related in vitreous fluid of patients with proliferative diabetic retinopathy.增殖性糖尿病视网膜病变患者玻璃体液中一氧化氮和血管内皮生长因子浓度升高，但二者无相关性。
Diabet Med. 2002 Aug;19(8):655-60. doi: 10.1046/j.1464-5491.2002.00768.x.
7
Comparison of serum NO, TNF-alpha, IL-1beta, sIL-2R, IL-6 and IL-8 levels with grades of retinopathy in patients with diabetes mellitus.糖尿病患者血清一氧化氮、肿瘤坏死因子-α、白细胞介素-1β、可溶性白细胞介素-2受体、白细胞介素-6和白细胞介素-8水平与视网膜病变分级的比较。
Eye (Lond). 2002 Mar;16(2):163-70. doi: 10.1038/sj.eye.6700095.
8
Direct quantitative differentiation between Prevotella intermedia and Prevotella nigrescens in clinical specimens.临床标本中中间普氏菌和变黑普氏菌的直接定量鉴别
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9
Nitric oxide and bone.一氧化氮与骨骼
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10
Expression of cytokines and inducible nitric oxide synthase in inflamed gingival tissue.细胞因子及诱导型一氧化氮合酶在炎症牙龈组织中的表达
J Periodontol. 2001 May;72(5):590-7. doi: 10.1902/jop.2001.72.5.590.

糖尿病伴牙周病患者龈沟液中的促炎和抗菌性一氧化氮

Proinflammatory and antimicrobial nitric oxide in gingival fluid of diabetic patients with periodontal disease.

作者信息

Skaleric Uros, Gaspirc Boris, McCartney-Francis Nancy, Masera Andrej, Wahl Sharon M

机构信息

Department of Oral Medicine & Periodontology, Faculty of Medicine, Hrvatski trg 6, 1000 Ljubljana, Slovenia.

出版信息

Infect Immun. 2006 Dec;74(12):7010-3. doi: 10.1128/IAI.00071-06. Epub 2006 Oct 2.

DOI:10.1128/IAI.00071-06
PMID:17015454
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1698046/
Abstract

Abnormal nitric oxide (NO) synthesis has been implicated in the pathogenesis of both periodontal disease and diabetes mellitus. In diabetic patients, increased inducible NO synthase in inflamed gingiva correlated with NO in gingival crevicular fluid. Although increased NO reflected more-severe inflammation, it was associated with reductions in CFU of Prevotella intermedia, a major periodontopathogen, highlighting dual roles for NO.

摘要

异常的一氧化氮（NO）合成与牙周病和糖尿病的发病机制均有关联。在糖尿病患者中，炎症牙龈中诱导型NO合酶的增加与龈沟液中的NO相关。尽管NO增加反映了更严重的炎症，但它与主要牙周病原体中间普氏菌的集落形成单位减少有关，这突出了NO的双重作用。