糖尿病伴牙周病患者龈沟液中的促炎和抗菌性一氧化氮
Proinflammatory and antimicrobial nitric oxide in gingival fluid of diabetic patients with periodontal disease.
作者信息
Skaleric Uros, Gaspirc Boris, McCartney-Francis Nancy, Masera Andrej, Wahl Sharon M
机构信息
Department of Oral Medicine & Periodontology, Faculty of Medicine, Hrvatski trg 6, 1000 Ljubljana, Slovenia.
出版信息
Infect Immun. 2006 Dec;74(12):7010-3. doi: 10.1128/IAI.00071-06. Epub 2006 Oct 2.
Abstract
Abnormal nitric oxide (NO) synthesis has been implicated in the pathogenesis of both periodontal disease and diabetes mellitus. In diabetic patients, increased inducible NO synthase in inflamed gingiva correlated with NO in gingival crevicular fluid. Although increased NO reflected more-severe inflammation, it was associated with reductions in CFU of Prevotella intermedia, a major periodontopathogen, highlighting dual roles for NO.
摘要
异常的一氧化氮（NO）合成与牙周病和糖尿病的发病机制均有关联。在糖尿病患者中，炎症牙龈中诱导型NO合酶的增加与龈沟液中的NO相关。尽管NO增加反映了更严重的炎症，但它与主要牙周病原体中间普氏菌的集落形成单位减少有关，这突出了NO的双重作用。
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