兴安过路黄中的三萜皂苷。

Triterpenoid saponins from Lysimachia davurica.

作者信息

Liang Bo, Tian Jing-Kui, Xu Li-Zhen, Yang Shi-Lin

机构信息

Department of Chinese Medicine Science and Engineering, Zhejiang University, Hangzhou, PR China.

出版信息

Chem Pharm Bull (Tokyo). 2006 Oct;54(10):1380-3. doi: 10.1248/cpb.54.1380.

DOI:10.1248/cpb.54.1380

PMID:17015973

Abstract

Three new saponins were isolated from the whole plants of Lysimachia davurica. On the basis of 1D and 2D NMR ((1)H-(1)HCOSY, HMBC, HMQC, and TOCSY) techniques, MS, and hydrolysis, their structures were found to be 3-O-beta-D-glucopyranosyl-(1-->2)-[beta-D-glucopyranosyl-(1-->4)]-alpha-L-arabinopyranosyl-13,28-epoxy-3beta-hydroxy-16-oleanaone (1), 3-O-beta-D-glucopyranosyloxyuronic acid-(1-->2)-beta-D-xylopyranosyl-cyclamiretin A (2), and 3-O-beta-D-glucopyranosyl-(1-->2)-alpha-L-arabinopyranosyl-cyclamiretin A (3), respectively. Compounds 2 and 3 showed significant cytotoxicities against human A-2780 cells.

摘要

从黄海棠全草中分离出三种新的皂苷。基于一维和二维核磁共振（（1）H-（1）HCOSY、HMBC、HMQC和TOCSY）技术、质谱和水解反应，发现它们的结构分别为3-O-β-D-吡喃葡萄糖基-（1→2）-[β-D-吡喃葡萄糖基-（1→4）]-α-L-吡喃阿拉伯糖基-13,28-环氧-3β-羟基-16-齐墩果烷酮（1）、3-O-β-D-吡喃葡萄糖醛酸基-（1→2）-β-D-吡喃木糖基-环阿尔廷醇A（2）和3-O-β-D-吡喃葡萄糖基-（1→2）-α-L-吡喃阿拉伯糖基-环阿尔廷醇A（3）。化合物2和3对人A-2780细胞显示出显著的细胞毒性。