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[硬金属病的一个特殊病例]

[A particular case of hard metal disease].

作者信息

Todaro A, Vitelli Nora, Riboldi L, Maggi L, Belotti Luisa, Mosconi G

机构信息

Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Dipartimento di Medicina del Lavoro, Clinica del Lavoro L. Devoto, Milano.

出版信息

Med Lav. 2006 Jul-Aug;97(4):586-91.

Abstract

BACKGROUND

The production and the use of hard metal tools have becoming increasingly widespread since the second half of the last century also thanks to the great variety of applications that extends from DIY to the aeronautical industry. It has already been known for many years that occupational exposure to hard metals dusts (which occurs especially in people employed in production of the metals or in the sharpening of tools that contain them) can determine the onset of pulmonary fibrosis, bronchial asthma and contact dermatitis.

OBJECTIVES

clinical evaluation of a peculiar case of hard metal disease. Descriptions of cases with single pathological pictures due to hard metals, are, in fact, common in the literature, neither are cases with two different clinical pictures (more frequently asthma and pulmonary fibrosis) rare. However, cases in which all the signs and symptoms appeared simultaneously have never been reported.

METHODS

a male worker aged 41 years, employed i a hard metal factory for seven years in sintering, and then in grinding. A year later he developed dry cough, wheeze, and eczematous patches. The diagnosis of hard metal disease was based on the work-related symptoms, clinical evaluation, spirometry, chest x-ray, HRCT and patch tests.

RESULTS

during the working period, ventilatory function decreased substantially, and then normalized one month after the patient stopped working. Patch tests confirmed sensitivity to cobalt, and skin lesions improved, as did ventilatory function. Chest x-ray and HRCT showed a pulmonary fibrosis that, at the last radiological examination, was still unchanged.

CONCLUSIONS

The particular susceptibility to the development of the diseases, could, in our opinion, be in relationship with the race of the subject, many studies (particularly American) have shown that allergic diseases are more frequent, and often more serious, in African subjects, particularly in immigrants from Africa. In the case of occupational diseases attention also needs to be given to the fact that immigrants are often employed in duties that involve a greater exposure to harmful or sensitizing agents. The occurrence of a whole series of occupational allergic diseases among these workers is therefore to be expected.

摘要

背景

自上世纪下半叶以来,硬质合金工具的生产和使用日益广泛,这也得益于其从DIY到航空工业的广泛应用。多年来人们已经知道,职业性接触硬质合金粉尘(尤其发生在从事金属生产或含硬质合金工具磨削工作的人员中)可导致肺纤维化、支气管哮喘和接触性皮炎。

目的

对一例特殊的硬质合金病病例进行临床评估。事实上,文献中常见因硬质合金导致单一病理表现的病例描述,出现两种不同临床表现(较常见的是哮喘和肺纤维化)的病例也不少见。然而,从未有过所有体征和症状同时出现的病例报道。

方法

一名41岁男性工人,在一家硬质合金工厂从事烧结工作7年,之后从事磨削工作。一年后,他出现干咳、喘息和湿疹斑。硬质合金病的诊断基于与工作相关的症状、临床评估、肺功能测定、胸部X光、高分辨率CT(HRCT)和斑贴试验。

结果

在工作期间,通气功能大幅下降,患者停止工作一个月后通气功能恢复正常。斑贴试验证实对钴过敏,皮肤病变改善,通气功能也有所改善。胸部X光和HRCT显示有肺纤维化,在最后一次影像学检查时仍无变化。

结论

我们认为,个体对疾病发展的特殊易感性可能与种族有关,许多研究(尤其是美国的研究)表明,过敏性疾病在非洲人群中更常见,且往往更严重,特别是非洲移民。在职业病方面,还需要注意移民往往从事接触有害或致敏剂风险更高的工作。因此,预计这些工人中会出现一系列职业性过敏性疾病。

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