Sakamoto Osamu, Kosai Sachiyo, Kohrogi Hirotsugu
Department of Respiratory Medicine, Kumamoto University Hospital, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University.
Nihon Kokyuki Gakkai Zasshi. 2008 Jul;46(7):535-41.
A 35-year-old man was admitted to our hospital because of abnormal shadows on the chest radiograph and dry cough and exertional dyspnea. He was given a diagnosis of hard metal lung disease 15 years previously and was treated with corticosteroid. Laboratory examination revealed hypoxemia and reduced pulmonary vital capacity. Chest radiograph and high-resolution computed tomography (HRCT) on admission showed ground-glass opacities with volume loss and small cystic spaces. Bronchoalveolar lavage fluid (BALF) demonstrated bizarre multinucleated giant cells and transbronchial lung biopsy (TBLB) specimens showed interstitial pneumonia with multinucleated giant cells. He has worked as a metal grinder, and tungsten was detected in his BALF metal analysis. His illness was diagnosed as hard metal lung disease with giant cell interstitial pneumonia (GIP). We considered this case as a type of chronic hypersensitivity pneumonitis due to his high sensitivity and his disease worsened gradually for four years. Since hard metal lung disease may recur in individuals with high sensitivity, we should always be aware of the possibility of recurrence of this disease.
一名35岁男性因胸部X线片出现异常阴影、干咳及劳力性呼吸困难入院。他于15年前被诊断为硬金属肺病,并接受了皮质类固醇治疗。实验室检查显示低氧血症和肺肺活量降低。入院时胸部X线片和高分辨率计算机断层扫描(HRCT)显示磨玻璃样影伴肺容积缩小及小囊腔。支气管肺泡灌洗液(BALF)显示怪异的多核巨细胞,经支气管肺活检(TBLB)标本显示伴有多核巨细胞的间质性肺炎。他从事金属研磨工作,其BALF金属分析检测到钨。他的疾病被诊断为伴有巨细胞间质性肺炎(GIP)的硬金属肺病。由于他高度敏感且病情在四年间逐渐恶化,我们将此病例视为一种慢性超敏性肺炎。鉴于硬金属肺病在高敏个体中可能复发,我们应始终意识到该病复发的可能性。