Hallett M
Human Motor Control Section, NINDS, NIH, Bethesda, MD, USA.
J Neural Transm Suppl. 2006(70):485-8. doi: 10.1007/978-3-211-45295-0_72.
Understanding of the pathophysiology of dystonia derives primarily from studies of focal dystonias. Physiological investigations have revealed a number of abnormalities that may reflect the genetic substrate that predisposes certain individuals to develop dystonia. There is a loss of inhibition in the central nervous system, and a loss of surround inhibition specifically. Plasticity is increased, and there are sensory abnormalities. Which of these disorders is primary is uncertain.
对肌张力障碍病理生理学的理解主要源于对局限性肌张力障碍的研究。生理学研究揭示了一些异常情况，这些异常可能反映了使某些个体易患肌张力障碍的遗传基础。中枢神经系统存在抑制功能丧失，尤其是周围抑制功能丧失。可塑性增加，并且存在感觉异常。这些病症中哪一种是原发性的尚不确定。
