Citron Diane M, Appleman Maria D
Microbial Research Lab, 2G-24, LAC+USC Medical Center, 1801 Marengo Street, Los Angeles, CA 90033, USA.
J Clin Microbiol. 2006 Oct;44(10):3814-8. doi: 10.1128/JCM.00881-06.
Daptomycin inhibited 67 of 70 clinical isolates of Bacillus species at < or =1 microg/ml and 100% of them at < or =2 microg/ml. It showed bactericidal activity similar to that of ciprofloxacin against vegetative cells but not against spores. For 2 strains, the ciprofloxacin MICs were >4 g/ml, and 10 strains were resistant to erythromycin.
达托霉素对70株芽孢杆菌临床分离株中的67株在浓度≤1微克/毫升时具有抑制作用,在浓度≤2微克/毫升时对所有菌株均有抑制作用。它对营养细胞显示出与环丙沙星相似的杀菌活性,但对芽孢无杀菌活性。有2株菌株的环丙沙星最低抑菌浓度>4微克/毫升,10株菌株对红霉素耐药。