Giannoglou G, Giannakoulas G, Soulis J, Chatzizisis Y, Perdikides T, Melas N, Parcharidis G, Louridas G
Cardiovascular Engineering and Atherosclerosis Laboratory, 1st Cardiology Department, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, 1 St. Kyriakidi Str, 54637, Thessaloniki, Greece.
Angiology. 2006 Aug-Sep;57(4):487-94. doi: 10.1177/0003319706290741.
The authors estimated noninvasively the wall stress distribution for actual abdominal aortic aneurysms (AAAs) in vivo on a patient-to-patient basis and correlated the peak wall stress (PWS) with various geometrical parameters. They studied 39 patients (37 men, mean age 73.7 +/- 8.2 years) with an intact AAA (mean diameter 6.3 +/- 1.7 cm) undergoing preoperative evaluation with spiral computed tomography (CT). Real 3-dimensional AAA geometry was obtained from image processing. Wall stress was determined by using a finite-element analysis. The aorta was considered isotropic with linear material properties and was loaded with a static pressure of 120.0 mm Hg. Various geometrical parameters were used to characterize the AAAs. PWS and each of the geometrical characteristics were correlated by use of Pearson's rank correlation coefficients. PWS varied from 10.2 to 65.8 N/cm2 (mean value 37.1 +/- 9.9 N/cm2). Among the geometrical parameters, the PWS was well correlated with the mean centerline curvature, the maximum centerline curvature, and the maximum centerline torsion of the AAAs. The correlation of PWS with maximum diameter was nonsignificant. Multiple regression analysis revealed that the mean centerline curvature of the AAA was the only significant predictor of PWS and subsequent rupture risk. This noninvasive computational approach showed that geometrical parameters other than the maximum diameter are better indicators of AAA rupture.
作者在患者个体基础上对实际腹主动脉瘤（AAA）在体内的壁应力分布进行了无创估计，并将峰值壁应力（PWS）与各种几何参数相关联。他们研究了39例（37名男性，平均年龄73.7±8.2岁）患有完整AAA（平均直径6.3±1.7 cm）的患者，这些患者正在接受螺旋计算机断层扫描（CT）术前评估。通过图像处理获得真实的三维AAA几何形状。使用有限元分析确定壁应力。主动脉被认为具有线性材料特性的各向同性，并承受120.0 mmHg的静压力。使用各种几何参数来表征AAA。通过使用Pearson等级相关系数将PWS与每个几何特征相关联。PWS范围为10.2至65.8 N/cm²（平均值37.1±9.9 N/cm²）。在几何参数中，PWS与AAA的平均中心线曲率、最大中心线曲率和最大中心线扭转密切相关。PWS与最大直径的相关性不显著。多元回归分析显示，AAA的平均中心线曲率是PWS和随后破裂风险的唯一显著预测因子。这种无创计算方法表明，除最大直径外的几何参数是AAA破裂的更好指标。
