Department of Vascular Surgery, University of Crete Medical School, Heraklion, Greece.
Eur J Vasc Endovasc Surg. 2010 Jan;39(1):42-8. doi: 10.1016/j.ejvs.2009.09.026. Epub 2009 Nov 10.
To study the correlation between peak wall stress (PWS) and abdominal aorta aneurysm (AAA) geometric parameters in the presence of intraluminal thrombus (ILT).
Computational study using finite element analysis.
AAA models were created by three-dimensional (3D) reconstruction of in vivo acquired computed tomography (CT) images from 19 patients.
PWS was evaluated in the presence and absence of ILT. DeltaPWS% represents the percentage change in PWS in the presence of ILT. The 3D lumen centrelines were extracted, and the values of torsion, tortuosity and mean curvature were estimated.
A positive correlation was observed between DeltaPWS% and relative ILT volume (P=0.03). PWS in the presence of ILT significantly correlated only with the degree of centerline tortuosity (P=0.003) and maximum diameter (P<0.0001). The optimal predictive model for PWS in the presence of ILT was estimated to contain both maximum diameter and centreline tortuosity.
Specific geometric parameters in AAA models in the presence of ILT could serve as potential predictors of elevated PWS. PWS correlated significantly with the maximum diameter and the degree of centreline tortuosity. Centreline tortuosity may become a useful addition to maximum diameter in the decision-making process of AAA treatment.
研究存在腔内血栓（ILT）时峰值壁应力（PWS）与腹主动脉瘤（AAA）几何参数之间的相关性。
使用有限元分析进行计算研究。
通过对 19 名患者体内获得的计算机断层扫描（CT）图像进行三维（3D）重建，创建了 AAA 模型。
评估了存在和不存在 ILT 时的 PWS。DeltaPWS% 表示存在 ILT 时 PWS 的百分比变化。提取了 3D 管腔中心线，并估计了扭转、曲折和平均曲率的值。
观察到 DeltaPWS%与相对 ILT 体积之间存在正相关（P=0.03）。存在 ILT 时的 PWS 仅与中心线曲折度（P=0.003）和最大直径（P<0.0001）显著相关。存在 ILT 时 PWS 的最佳预测模型估计包含最大直径和中心线曲折度。
存在 ILT 的 AAA 模型中的特定几何参数可以作为升高的 PWS 的潜在预测因子。PWS 与最大直径和中心线曲折度显著相关。中心线曲折度可能在 AAA 治疗决策过程中成为最大直径的有用补充。
