Devaraj Sridevi, Autret Bryce C, Jialal Ishwarlal
Laboratory for Atherosclerosis and Metabolic Research and General Clinical Research Center, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Am J Clin Nutr. 2006 Oct;84(4):756-61. doi: 10.1093/ajcn/84.4.756.
Dietary plant sterols effectively reduce LDL cholesterol when incorporated into fat matrices. We showed previously that supplementation with orange juice containing plant sterols (2 g/d) significantly reduced LDL cholesterol. Inflammation is pivotal in atherosclerosis. High-sensitivity C-reactive protein (hs-CRP), the prototypic marker of inflammation, is a cardiovascular disease risk marker; however, there is a paucity of data on the effect of plant sterols on CRP concentrations.
The aim of this study was to examine whether plant sterols affect CRP concentrations and the lipoprotein profile when incorporated into a reduced-calorie (50 calories/240 mL) orange juice beverage.
Seventy-two healthy subjects were randomly assigned to receive a reduced-calorie orange juice beverage either without (Placebo Bev) or with (1 g/240 mL; Sterol Bev) plant sterols twice a day with meals for 8 wk. Fasting blood was obtained at baseline and after 8 wk of Placebo Bev or Sterol Bev supplementation.
Sterol Bev supplementation significantly reduced total cholesterol (5%; P < 0.01) and LDL cholesterol (9.4%; P < 0.001) compared with both baseline and Placebo Bev (P < 0.05). HDL cholesterol increased significantly with Sterol Bev (P < 0.02). No significant changes in triacylglycerol, glucose, or liver function tests were observed with Sterol Bev. Sterol Bev supplementation resulted in no significant change in vitamin E and carotenoid concentrations. Sterol Bev supplementation resulted in a significant reduction of CRP concentrations compared with baseline and Placebo Bev (median reduction: 12%; P < 0.005).
Supplementation with a reduced-calorie orange juice beverage containing plant sterols is effective in reducing CRP and LDL cholesterol and could be incorporated into the dietary portion of therapeutic lifestyle changes.
将膳食植物甾醇添加到脂肪基质中可有效降低低密度脂蛋白胆固醇。我们之前的研究表明，补充含植物甾醇的橙汁（2克/天）可显著降低低密度脂蛋白胆固醇。炎症在动脉粥样硬化中起关键作用。高敏C反应蛋白（hs-CRP）作为炎症的典型标志物，是心血管疾病的风险标志物；然而，关于植物甾醇对CRP浓度影响的数据却很少。
本研究旨在探讨将植物甾醇添加到低热量（50卡路里/240毫升）橙汁饮料中时，是否会影响CRP浓度和脂蛋白谱。
72名健康受试者被随机分配，分别接受不含植物甾醇的低热量橙汁饮料（安慰剂饮料）或含植物甾醇（1克/240毫升；甾醇饮料）的低热量橙汁饮料，每天随餐服用两次，持续8周。在基线时以及服用安慰剂饮料或甾醇饮料8周后采集空腹血样。
与基线和安慰剂饮料相比，补充甾醇饮料可显著降低总胆固醇（5%；P<0.01）和低密度脂蛋白胆固醇（9.4%；P<0.001）（P<0.05）。补充甾醇饮料后高密度脂蛋白胆固醇显著升高（P<0.02）。服用甾醇饮料后，甘油三酯、血糖或肝功能检查均未观察到显著变化。补充甾醇饮料后，维生素E和类胡萝卜素浓度无显著变化。与基线和安慰剂饮料相比，补充甾醇饮料可使CRP浓度显著降低（中位数降低：12%；P<0.005）。
补充含植物甾醇的低热量橙汁饮料可有效降低CRP和低密度脂蛋白胆固醇，并可纳入治疗性生活方式改变的饮食部分。
