Lopez-Garcia Esther, van Dam Rob M, Qi Lu, Hu Frank B
Department of Nutrition and Epidemiology, Harvard Medical School, Boston, MA, USA.
Am J Clin Nutr. 2006 Oct;84(4):888-93. doi: 10.1093/ajcn/84.4.888.
In several short-term studies, coffee consumption has been associated with impairment of endothelial function.
The objective was to assess the relation between long-term caffeinated and decaffeinated filtered coffee consumption and markers of inflammation and endothelial dysfunction.
We conducted a cross-sectional study of 730 healthy women and 663 women with type 2 diabetes from the Nurses' Health Study I cohort, who were aged 43-70 y and free of cardiovascular disease and cancer at the time blood was drawn (1989-1990). Dietary intake was assessed with a validated food-frequency questionnaire in 1986 and 1990.
About 77% of the healthy women consumed > or =1 cup (237 mL) caffeinated coffee/mo and 75% consumed > or =1 cup decaffeinated coffee/mo; the corresponding intakes for women with type 2 diabetes were 74% and 63%, respectively. In healthy women, no appreciable differences in plasma concentrations of the markers were found across categories of caffeinated coffee intake. In women with type 2 diabetes, higher caffeinated coffee consumption was associated with lower plasma concentrations of E-selectin (adjusted percentage change per 1 cup/d increment = -3.2%; P = 0.05) and C-reactive protein (adjusted percentage change = -10.2%; P < 0.001). Higher decaffeinated coffee consumption was associated with lower plasma concentrations of E-selectin (adjusted percentage change = -2.5%; P = 0.08) and C-reactive protein (adjusted percentage change = -7.9%; P = 0.02) only in healthy women. The results were similar when we also adjusted the models for other dietary factors and blood lipids and when we excluded participants with hypertension or hypercholesterolemia.
These results indicate that neither caffeinated nor decaffeinated filtered coffee has a detrimental effect on endothelial function. In contrast, the results suggest that coffee consumption is inversely associated with markers of inflammation and endothelial dysfunction.
在几项短期研究中，饮用咖啡与内皮功能受损有关。
评估长期饮用含咖啡因和不含咖啡因的过滤咖啡与炎症标志物及内皮功能障碍之间的关系。
我们对来自护士健康研究I队列的730名健康女性和663名2型糖尿病女性进行了一项横断面研究，她们年龄在43 - 70岁之间，在抽血时（1989 - 1990年）无心血管疾病和癌症。1986年和1990年用经过验证的食物频率问卷评估饮食摄入量。
约77%的健康女性每月饮用≥1杯（237毫升）含咖啡因咖啡，75%的健康女性每月饮用≥1杯脱咖啡因咖啡；2型糖尿病女性的相应摄入量分别为74%和63%。在健康女性中，不同类别含咖啡因咖啡摄入量的血浆标志物浓度无明显差异。在2型糖尿病女性中，饮用更多含咖啡因咖啡与较低的血浆E - 选择素浓度相关（每增加1杯/天的调整百分比变化 = -3.2%；P = 0.05）和C反应蛋白浓度相关（调整百分比变化 = -10.2%；P < 0.001）。仅在健康女性中，饮用更多脱咖啡因咖啡与较低的血浆E - 选择素浓度相关（调整百分比变化 = -2.5%；P = 0.08）和C反应蛋白浓度相关（调整百分比变化 = -7.9%；P = 0.02）。当我们对模型调整其他饮食因素和血脂，以及排除高血压或高胆固醇血症参与者时，结果相似。
这些结果表明，含咖啡因和不含咖啡因的过滤咖啡对内皮功能均无有害影响。相反，结果表明饮用咖啡与炎症标志物及内皮功能障碍呈负相关。
