Lu Yingjuan, Yang Jun, Sega Emanuela
Endocyte, Inc, 3000 Kent Avenue, Suite A1-100, West Lafayette, IN 47906, USA.
AAPS J. 2006 Jul 21;8(3):E466-78. doi: 10.1208/aapsj080355.
While modern genomic and proteomic technology enables rapid screening of novel proteins and peptides as potential drug candidates, design of delivery systems for these biologics remains challenging especially to achieve site-specific pharmacological actions. This article discusses the issues associated with targeted delivery of protein and peptide drugs at physiochemical, physiological, and intracellular levels with a special focus on cancer therapy.
虽然现代基因组学和蛋白质组学技术能够快速筛选新型蛋白质和肽作为潜在的药物候选物，但这些生物制剂递送系统的设计仍然具有挑战性，尤其是要实现位点特异性药理作用。本文讨论了在物理化学、生理和细胞内水平上与蛋白质和肽类药物靶向递送相关的问题，特别关注癌症治疗。
