Hanke Felix, Kreuzer Hans Jürgen
Department of Physics and Atmospheric Science, Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5.
Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Sep;74(3 Pt 1):031909. doi: 10.1103/PhysRevE.74.031909. Epub 2006 Sep 22.
A theoretical framework is developed to analyze molecular bond breaking in dynamic force spectroscopy using atomic force microscopy. An analytic expression of the observed bond breaking probability as a function of force is obtained in terms of the relevant physical parameters. The force-ramp mode is discussed in detail, which gives the best framework to extract the relevant physical parameters such as the potential depth and its width, if a set of widely different force-loading rates are used. We also show that the commonly used Ritchie-Evans model is incomplete and that it is only applicable for forces well below the maximum permitted by the potential. Statistical complications arising from the use of constant velocity experiments are discussed in detail.
本文建立了一个理论框架，用于分析使用原子力显微镜的动态力谱中的分子键断裂。根据相关物理参数，得到了观测到的键断裂概率随力变化的解析表达式。详细讨论了力斜坡模式，若使用一组差异较大的力加载速率，该模式为提取诸如势阱深度及其宽度等相关物理参数提供了最佳框架。我们还表明，常用的里奇 - 埃文斯模型并不完整，且仅适用于远低于势阱允许的最大力的情况。详细讨论了使用恒速实验产生的统计复杂性。
