Middleton Deborah, Bingham John, Selleck Paul, Lowther Sue, Gleeson Laurie, Lehrbach Philip, Robinson Simon, Rodenberg Jeff, Kumar Mahesh, Andrew Marion
Australian Animal Health Laboratory, CSIRO Livestock Industries, PO Bag 24, Geelong, Victoria, 3220 Australia.
Virology. 2007 Mar 1;359(1):66-71. doi: 10.1016/j.virol.2006.08.046. Epub 2006 Oct 9.
The current Asian H5N1 highly pathogenic avian influenza virus has spread over much of Asia and into Europe and Africa. As well as affecting village and commercial chicken operations in many South East Asian countries, it differs from past H5 avian influenza viruses in that it causes morbidity and mortalities in other domesticated birds, such as ducks and turkeys and in wild water birds. Effective vaccines that can prevent infection, as well as disease, and be used in a variety of avian species are needed for field use. In this report, a bivalent H5N9+H7N1 oil emulsion vaccine is compared, in ducks, to a monovalent H5N3 oil emulsion vaccine that has been derived by reverse genetics with an H5 from A/chicken/Vietnam/C58/04. While both vaccines protected against morbidity, the monovalent vaccine provided effective protection, with no evidence of shedding of the challenge virus and no serological response to the H5N1 challenge virus.
当前的亚洲H5N1高致病性禽流感病毒已在亚洲大部分地区传播，并蔓延至欧洲和非洲。除了影响许多东南亚国家的乡村和商业养鸡场之外，它与过去的H5禽流感病毒不同之处在于，它会导致其他家养禽类发病和死亡，如鸭、火鸡以及野生水鸟。需要有能预防感染和疾病、并可用于多种禽类的有效疫苗供现场使用。在本报告中，在鸭身上将一种二价H5N9+H7N1油乳剂疫苗与一种单价H5N3油乳剂疫苗进行了比较，后者是通过反向遗传学方法，采用A/鸡/越南/C58/04的H5研制而成的。虽然两种疫苗都能预防发病，但单价疫苗提供了有效的保护，没有发现感染病毒排出的迹象，也没有对H5N1攻击病毒产生血清学反应。
