Triesscheijn Martijn, Baas Paul, Schellens Jan H M, Stewart Fiona A
Division of Experimental Therapy (H6), The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Oncologist. 2006 Oct;11(9):1034-44. doi: 10.1634/theoncologist.11-9-1034.
Photodynamic therapy (PDT) is increasingly being recognized as an attractive, alternative treatment modality for superficial cancer. Treatment consists of two relatively simple procedures: the administration of a photosensitive drug and illumination of the tumor to activate the drug. Efficacy is high for small superficial tumors and, except for temporary skin photosensitization, there are no long-term side effects if appropriate protocols are followed. Healing occurs with little or no scarring and the procedure can be repeated without cumulative toxicity. Considering the efficacy and lack of long-term toxicity of PDT, and the fact that the first treatment of cancer with PDT was done more than 100 years ago, one might expect that this treatment had already become an established therapy. However, PDT is currently offered in only a few selected centers, although it is slowly gaining acceptance as an alternative to conventional cancer therapies. Here, we show the developmental steps PDT underwent and summarize the current clinical applications. The data show that, when properly used, PDT is an effective alternative treatment option in oncology.
光动力疗法（PDT）越来越被认为是一种针对浅表癌的有吸引力的替代治疗方式。治疗包括两个相对简单的步骤：给予光敏药物和照射肿瘤以激活药物。对于小的浅表肿瘤，疗效很高，并且除了暂时的皮肤光敏化外，如果遵循适当的方案，没有长期副作用。愈合时几乎没有或没有疤痕，并且该程序可以重复进行而不会产生累积毒性。考虑到PDT的疗效和缺乏长期毒性，以及PDT首次用于癌症治疗是在100多年前这一事实，人们可能会认为这种治疗已经成为一种既定的疗法。然而，尽管PDT作为传统癌症疗法的替代方法正在慢慢获得认可，但目前只有少数选定的中心提供这种疗法。在这里，我们展示了PDT所经历的发展步骤并总结了当前的临床应用。数据表明，当正确使用时，PDT是肿瘤学中一种有效的替代治疗选择。
