Smith Stacy R, Piacquadio Daniel J, Beger Brian, Littler Curt
Therapeutics, Inc., San Diego, California, USA.
Dermatol Surg. 2006 Oct;32(10):1237-43. doi: 10.1111/j.1524-4725.2006.32282.x.
Eflornithine cream is approved for the reduction of unwanted facial hair in women. The mechanism of action for eflornithine is reduction in follicular cell growth rate, while laser photoepilation heats hair and adjacent tissues to suspend growth.
The objective was to assess the efficacy and safety of eflornithine or vehicle with laser therapy in the treatment of unwanted facial hair in women.
Subjects were randomized to treatment with eflornithine on one side of the face and vehicle on the contralateral side for 34 weeks. Subjects received Nd:YAG or alexandrite laser therapy to both sides of the face at Weeks 2 and 10. Blinded evaluations included left to right comparisons and appearance relative to baseline.
Fifty-four women completed the trial. From Weeks 6 through 22, eflornithine-treated sides showed significant reduction in hair growth. By Week 34, no significant differences were seen. Subject grading showed significant and persistent hair reduction through Week 34 for eflornithine-treated sides. The safety profile for combination therapy is similar to eflornithine alone.
Eflornithine is safely used in conjunction with laser hair removal treatments and promotes more rapid hair removal when combined with laser treatment. Patients demonstrate a clear preference for treatment with laser and eflornithine.
依氟鸟氨酸乳膏已被批准用于减少女性面部多余毛发。依氟鸟氨酸的作用机制是降低毛囊细胞生长速度，而激光脱毛是通过加热毛发及相邻组织来抑制毛发生长。
评估依氟鸟氨酸或赋形剂联合激光治疗女性面部多余毛发的疗效和安全性。
将受试者随机分为两组，一侧面部使用依氟鸟氨酸治疗，对侧面部使用赋形剂治疗，为期34周。在第2周和第10周时，对受试者双侧面部进行钕:钇铝石榴石（Nd:YAG）激光或翠绿宝石激光治疗。盲法评估包括左右对比以及与基线相比的外观变化。
54名女性完成了试验。从第6周开始至第22周，使用依氟鸟氨酸治疗的一侧面部毛发生长显著减少。到第34周时，未观察到显著差异。受试者分级显示，在第34周时，使用依氟鸟氨酸治疗的一侧面部毛发持续显著减少。联合治疗的安全性与单独使用依氟鸟氨酸相似。
依氟鸟氨酸可安全地与激光脱毛治疗联合使用，并且与激光治疗联合时能促进更快速的毛发去除。患者明显更倾向于接受激光和依氟鸟氨酸联合治疗。
