Clarkson R M, Moule A J, Podlich H, Kellaway R, Macfarlane R, Lewis D, Rowell J
Aust Dent J. 2006 Sep;51(3):245-51. doi: 10.1111/j.1834-7819.2006.tb00437.x.
The solubility of dental pulp tissue in sodium hypochlorite has been extensively investigated but results have been inconsistent; due most likely to variations in experimental design, the volume and/or rate of replenishment of the solutions used and the nature of the tissues assessed. Traditionally, the sodium hypochlorite solutions used for endodontic irrigation in Australia have been either Milton or commercial bleach, with Milton being the most common. Recently, a range of Therapeutic Goods Administration (TGA) approved proprietary sodium hypochlorite solutions, which contain surfactant, has become available. Some domestic chlorine bleaches now also contain surfactants. The purpose of this study was to perform new solubility assessments, comparing Milton with new TGA approved products, Hypochlor 1% and Hypochlor 4% forte, and with a domestic bleach containing surfactant (White King).
Ten randomly assigned pulp samples of porcine dental pulp of approximately equal dimensions were immersed in the above solutions, as well as representative concentrations of sodium hydroxide. Time to complete dissolution was measured and assessed statistically.
White King 4% showed the shortest dissolution time, closely followed by Hypochlor 4% forte. White King 1% and Hypochlor 1% each took around three times as long to completely dissolve the samples of pulp as their respective 4% concentrations, while Milton took nearly 10 times as long. The sodium hydroxide solutions showed no noticeable dissolution of the pulp samples.
The composition and content of sodium hypochlorite solutions had a profound effect on the ability of these solutions to dissolve pulp tissue in vitro. Greater concentrations provided more rapid dissolution of tissue. One per cent solutions with added surfactant and which contained higher concentrations of sodium hydroxide were significantly more effective in dissolution of pulp tissue than Milton.
牙髓组织在次氯酸钠中的溶解性已得到广泛研究，但结果并不一致；这很可能是由于实验设计、所用溶液的补充量和/或速率以及所评估组织的性质存在差异。传统上，澳大利亚用于根管冲洗的次氯酸钠溶液要么是米尔顿溶液，要么是商业漂白剂，其中米尔顿溶液最为常见。最近，一系列经治疗用品管理局（TGA）批准的含有表面活性剂的专利次氯酸钠溶液已上市。现在一些家用含氯漂白剂也含有表面活性剂。本研究的目的是进行新的溶解性评估，将米尔顿溶液与新的TGA批准产品（1%次氯酸钠溶液和4%强力次氯酸钠溶液）以及一种含有表面活性剂的家用漂白剂（白国王）进行比较。
将十个随机分配的尺寸大致相等的猪牙髓样本浸入上述溶液以及代表性浓度的氢氧化钠溶液中。测量完全溶解的时间并进行统计学评估。
4%的白国王溶液显示出最短的溶解时间，紧随其后的是4%强力次氯酸钠溶液。1%的白国王溶液和1%次氯酸钠溶液完全溶解牙髓样本的时间分别是各自4%浓度溶液的三倍左右，而米尔顿溶液则花费了近十倍的时间。氢氧化钠溶液对牙髓样本没有明显的溶解作用。
次氯酸钠溶液的组成和含量对这些溶液在体外溶解牙髓组织的能力有深远影响。更高的浓度能使组织更快溶解。添加了表面活性剂且含有更高浓度氢氧化钠的1%溶液在溶解牙髓组织方面比米尔顿溶液显著更有效。
