Okino L A, Siqueira E L, Santos M, Bombana A C, Figueiredo J A P
Department of Endodontics, Dental School, Universidade de São Paulo, São Paulo, Brazil.
Int Endod J. 2004 Jan;37(1):38-41. doi: 10.1111/j.1365-2591.2004.00749.x.
To evaluate the activity of various root canal irrigants on bovine pulp tissue.
The irrigants tested were: 0.5, 1.0 and 2.5% sodium hypochlorite; 2% aqueous solution of chlorhexidine digluconate; 2% chlorhexidine digluconate gel (Natrosol); and distilled water as control. Bovine pulp fragments were weighed and placed in contact with 20 mL of each tested substance in a centrifuge at 150 r.p.m. until total dissolution. Dissolution speed was calculated by dividing pulp weight by dissolution time. Statistical analysis was performed using the Kruskal-Wallis test.
Distilled water and both solutions of chlorhexidine did not dissolve the pulp tissue within 6 h. Mean dissolution speeds for 0.5, 1.0 and 2.5% sodium hypochlorite solutions were 0.31, 0.43 and 0.55 mg min(-1), respectively. The solvent ability of chlorhexidine solutions was similar to that of distilled water. The results for sodium hypochlorite solutions, chlorhexidine solutions and distilled water were statistically different (P>0.01).
Both chlorhexidine preparations and distilled water were not able to dissolve pulp tissue. All sodium hypochlorite solutions were efficient in dissolving pulp tissue; the dissolution speed varied with the concentration of the solution.
评估各种根管冲洗剂对牛牙髓组织的活性。
所测试的冲洗剂有：0.5%、1.0%和2.5%的次氯酸钠；2%的葡萄糖酸氯己定水溶液；2%的葡萄糖酸氯己定凝胶（羟丙基甲基纤维素）；以及作为对照的蒸馏水。称取牛牙髓碎片，将其与20毫升每种测试物质在离心机中以每分钟150转的速度接触，直至完全溶解。溶解速度通过牙髓重量除以溶解时间来计算。采用Kruskal-Wallis检验进行统计分析。
蒸馏水和两种氯己定溶液在6小时内均未溶解牙髓组织。0.5%、1.0%和2.5%的次氯酸钠溶液的平均溶解速度分别为0.31、0.43和0.55毫克/分钟。氯己定溶液的溶解能力与蒸馏水相似。次氯酸钠溶液、氯己定溶液和蒸馏水的结果在统计学上有差异（P>0.01）。
氯己定制剂和蒸馏水均不能溶解牙髓组织。所有次氯酸钠溶液在溶解牙髓组织方面均有效；溶解速度随溶液浓度而变化。
