Burini D, Farabollini B, Iacucci S, Rimatori C, Riccardi G, Capecci M, Provinciali L, Ceravolo M G
Neurorehabilitation Clinic, Department of Neurosciences, Politecnica University of Marche, Azienda Ospedali Riuniti, Ancona, Italy.
Eura Medicophys. 2006 Sep;42(3):231-8.
To investigate the effects of an aerobic training in subjects with Parkinson's disease (PD) as compared to a medical Chinese exercise (Qigong).
randomized controlled trial with a cross over design.
PD out-patients referred to a Neurorehabilitation facility for the management of motor disability.
26 PD patients in Hoehn and Yahr stage II to III under stable medication were randomly allocated to either Group AT1+QG2 (receiving 20 aerobic training sessions followed by 20 ''Qigong'' group sessions with 2 month interval between the interventions), or Group QG1+AT2 (performing the same treatments with an inverted sequence).
clinical effects of treatment were sought through the Unified Parkinson's Disease Rating Scale (UPDRS), Brown's Disability Scale (B'DS), six-Minute Walking Test (6MWT), Borg scale for breathlessness, Beck Depression Inventory (BDI) and Parkinson's Disease Questionnaire-39 items (PDQ-39). A spirometry test and maximum cardiopulmonary exercise test (CPET) were also performed to determine the pulmonary function, the metabolic and cardio-respiratory requests at rest and under exercise. All measures were taken immediately before and at the completion of each treatment phase.
The statistical analysis focusing on the evolution of motor disability and quality of life revealed a significant interaction effect between group and time for the 6MWT (time x group effect: F: 5.4 P=0.002) and the Borg scale (time x group effect: F: 4.2 P=0.009). Post hoc analysis showed a significant increase in 6MWT and a larger decrease in Borg score after aerobic training within each subgroup, whereas no significant changes were observed during Qigong. No significant changes over time were detected through the analysis of UPDRS, B'DS, BDI and PDQ-39 scores. The analysis of cardiorespiratory parameters showed significant interaction effects between group and time for the Double Productpeak (time x group effect: F: 7.7 P=0.0003), the VO(2peak) (time x group effect: F: 4.8 P=0.007), and the VO(2)/kg ratio (time x group effect: F: 4.3 P=0.009), owing to their decrease after aerobic training to an extent that was never observed after Qigong treatment.
Aerobic training exerts a significant impact on the ability of moderately disabled PD patients to cope with exercise, although it does not improve their self-sufficiency and quality of life.
研究与中医运动（气功）相比，有氧训练对帕金森病（PD）患者的影响。
采用交叉设计的随机对照试验。
转至神经康复机构治疗运动障碍的PD门诊患者。
26例处于Hoehn和Yahr II至III期且药物治疗稳定的PD患者，被随机分配至AT1+QG2组（接受20次有氧训练课程，随后进行20次“气功”组课程，两次干预之间间隔2个月）或QG1+AT2组（以相反顺序进行相同治疗）。
通过统一帕金森病评定量表（UPDRS）、布朗残疾量表（B'DS）、六分钟步行试验（6MWT）、呼吸困难Borg量表、贝克抑郁量表（BDI）和帕金森病39项问卷（PDQ-39）来寻求治疗的临床效果。还进行了肺活量测定试验和最大心肺运动试验（CPET），以确定肺功能、静息和运动时的代谢及心肺需求。所有测量均在每个治疗阶段开始前和结束时立即进行。
针对运动障碍演变和生活质量的统计分析显示，6MWT（时间×组效应：F：5.4，P=0.002）和Borg量表（时间×组效应：F：4.2，P=0.009）在组和时间之间存在显著交互作用。事后分析表明，每个亚组在有氧训练后6MWT显著增加，Borg评分下降幅度更大，而在气功训练期间未观察到显著变化。通过对UPDRS、B'DS、BDI和PDQ-39评分的分析，未发现随时间的显著变化。心肺参数分析显示，双乘积峰值（时间×组效应：F：7.7，P=0.0003）、VO₂峰值（时间×组效应：F：4.8，P=0.007）和VO₂/kg比值（时间×组效应：F：4.3，P=0.009）在组和时间之间存在显著交互作用，因为它们在有氧训练后下降的程度在气功治疗后从未观察到。
有氧训练对中度残疾的PD患者应对运动的能力有显著影响，尽管它并不能改善他们的自理能力和生活质量。
