Yildiz Tulay Sahin, Toprak Demet Gedikbasi, Arisoy Emin Sami, Solak Mine, Toker Kamil
Department of Anaesthesiology, School of Medicine, University of Kocaeli, Kocaeli, Turkey.
Paediatr Anaesth. 2006 Nov;16(11):1176-8. doi: 10.1111/j.1460-9592.2006.01955.x.
Carbamazepine (CBZ) intoxication is an important issue in acute poisoning practice. Highly protein-bound, CBZ is not removed efficiently through conventional hemodialysis. We describe the use of continuous venovenous hemodiafiltration (CVVHDF) in a 2-year-old boy who developed general tonic clonic seizure and respiratory depression due to controlled-release formula of CBZ overdose (peak drug level of > 20 microg.ml(-1), therapeutic range: 5-10 microg.ml(-1)). Serum CBZ concentrations fell to 0.25 microg.ml(-1) at the end of hemodiafiltration. The patient recovered rapidly and was discharged from hospital 4 days from the time of ingestion with no complications or neurologic impairment.
卡马西平（CBZ）中毒是急性中毒诊治中的一个重要问题。由于CBZ与蛋白质高度结合，常规血液透析无法有效清除。我们描述了在一名2岁男孩中使用连续性静脉-静脉血液透析滤过（CVVHDF）的情况，该男孩因服用控释剂型的卡马西平过量（药物峰值水平>20μg·ml⁻¹，治疗范围：5 - 10μg·ml⁻¹）而出现全身强直阵挛性发作和呼吸抑制。血液透析滤过结束时血清卡马西平浓度降至0.25μg·ml⁻¹。患者恢复迅速，自摄入药物后4天出院，无并发症或神经功能损害。
