Holzner B, Bode R K, Hahn E A, Cella D, Kopp M, Sperner-Unterweger B, Kemmler G
Department of Psychiatry, Innsbruck University Hospital, Anichstr.35, A-6020 Innsbruck, Austria.
Eur J Cancer. 2006 Dec;42(18):3169-77. doi: 10.1016/j.ejca.2006.08.016. Epub 2006 Oct 11.
To investigate the equivalence of the European Organization for Research and Treatment of Cancer Core Questionnaire (EORTC QLQ-C30) and the Functional Assessment for Cancer Therapy-General (FACT-G) on the basis of corresponding subscales, and where appropriate to derive a scheme for converting QLQ-C30 scores into FACT-G scores and vice versa for use in oncological research.
A calibration sample of 737 cancer patients (mean age 51.4+/-7.6 (SD), 63% female, 25% with current chemotherapy) who filled in both quality of life (QOL) questionnaires was used. Both classical test theory and the Rasch measurement model were applied.
Three of the four subscales common to both QOL instruments (physical, emotional, functional) proved suitable for equating (acceptable inter-correlations of corresponding subscales physical (r=0.77), emotional domain (r=0.60) role/functional (r=0.63) relative to their internal consistency, sufficient unidimensionality of pooled subscales, satisfactory fit to the Rasch model). Conversion tables for these subscales were generated.
The conversion tables developed in this study (physical, emotional and functional/role domain) appear promising for the comparison between EORTC QLQ-C30 and FACT-G scores of patient samples.
基于相应子量表研究欧洲癌症研究与治疗组织核心问卷（EORTC QLQ-C30）与癌症治疗功能评估通用量表（FACT-G）的等效性，并在适当情况下制定将QLQ-C30分数转换为FACT-G分数以及反之的方案，以供肿瘤学研究使用。
使用了737名癌症患者的校准样本（平均年龄51.4±7.6（标准差），63%为女性，25%正在接受化疗），这些患者填写了两份生活质量（QOL）问卷。同时应用了经典测试理论和拉施测量模型。
两种QOL工具共有的四个子量表中的三个（身体、情感、功能）被证明适用于等效性评估（相应子量表身体（r = 0.77）、情感领域（r = 0.60）、角色/功能（r = 0.63）相对于其内部一致性具有可接受的相互相关性，合并子量表具有足够的单维度性，对拉施模型拟合良好）。生成了这些子量表的转换表。
本研究中开发的转换表（身体、情感和功能/角色领域）对于比较患者样本的EORTC QLQ-C30和FACT-G分数似乎很有前景。
