来自肌醇焦磷酸InsP5PP和InsP4(PP)2的磷酸转移：一项半经验研究。
Phosphate transfer from inositol pyrophosphates InsP5PP and InsP4(PP)2: a semi-empirical investigation.
作者信息
Hand Christine E, Honek John F
机构信息
Department of Chemistry, University of Waterloo, 200 University Avenue West, Waterloo, Ont., Canada.
出版信息
Bioorg Med Chem Lett. 2007 Jan 1;17(1):183-8. doi: 10.1016/j.bmcl.2006.09.066. Epub 2006 Oct 10.
PMID:17045478
Abstract
A novel phosphate transfer process involving the non-enzymatic transfer of a phosphate group from inositol pyrophosphates to serine residues in proteins has been recently reported. Semi-empirical calculations at the PM3/SM5.2 level were undertaken to explore the effect of inositol pyrophosphate structure and overall charge on the thermodynamics of this phosphate transfer.
摘要
最近报道了一种新的磷酸转移过程，该过程涉及磷酸基团从肌醇焦磷酸非酶促转移至蛋白质中的丝氨酸残基。采用PM3/SM5.2水平的半经验计算来探究肌醇焦磷酸结构和总电荷对这种磷酸转移热力学的影响。
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