Hand Christine E, Honek John F
Department of Chemistry, University of Waterloo, 200 University Avenue West, Waterloo, Ont., Canada.
Bioorg Med Chem Lett. 2007 Jan 1;17(1):183-8. doi: 10.1016/j.bmcl.2006.09.066. Epub 2006 Oct 10.
A novel phosphate transfer process involving the non-enzymatic transfer of a phosphate group from inositol pyrophosphates to serine residues in proteins has been recently reported. Semi-empirical calculations at the PM3/SM5.2 level were undertaken to explore the effect of inositol pyrophosphate structure and overall charge on the thermodynamics of this phosphate transfer.
最近报道了一种新的磷酸转移过程，该过程涉及磷酸基团从肌醇焦磷酸非酶促转移至蛋白质中的丝氨酸残基。采用PM3/SM5.2水平的半经验计算来探究肌醇焦磷酸结构和总电荷对这种磷酸转移热力学的影响。
