Kyrkouli S E, Stanley B G, Seirafi R D, Leibowitz S F
Rockefeller University, New York, NY 10010.
Peptides. 1990 Sep-Oct;11(5):995-1001. doi: 10.1016/0196-9781(90)90023-x.
The neuropeptide galanin (GAL) has been found to elicit eating after injection into the hypothalamic paraventricular nucleus (PVN). To determine whether GAL's effect in the brain is anatomically specific, this peptide (0.1 or 0.3 nmol) was microinjected into one of 14 different brain areas of rats, and its impact on subsequent food intake was measured. Among the hypothalamic sites tested, only the PVN and the adjacent periventricular region yielded a significant eating response to GAL. With injection into the PVN, a feeding response was observed without apparent changes in other food-associated behaviors, e.g., drinking, grooming, resting and sleeping, or low and high levels of activity. All other hypothalamic and extrahypothalamic sites tested were unresponsive to GAL, with the exception of the amygdala where a significant eating response was observed. These findings suggest that central GAL elicits feeding by acting in an anatomically localized and behaviorally specific manner. In light of other pharmacological and anatomical evidence, it is suggested the PVN GAL, in modulating feeding behavior, may work in association with the catecholamine norepinephrine (NE) which is known to coexist with GAL in PVN neurons.
已发现神经肽甘丙肽（GAL）注入下丘脑室旁核（PVN）后会引发进食行为。为了确定GAL在大脑中的作用是否具有解剖学特异性，将这种肽（0.1或0.3纳摩尔）微量注入大鼠14个不同脑区中的一个，并测量其对随后食物摄入量的影响。在所测试的下丘脑部位中，只有PVN和相邻的室周区域对GAL产生了显著的进食反应。注入PVN后，观察到进食反应，而其他与食物相关的行为，如饮水、梳理毛发、休息和睡眠或低水平和高水平活动，均无明显变化。除杏仁核观察到显著的进食反应外，所有其他测试的下丘脑和下丘脑外部位对GAL均无反应。这些发现表明，中枢GAL通过以解剖学定位和行为特异性的方式起作用来引发进食。根据其他药理学和解剖学证据，提示PVN中的GAL在调节进食行为时，可能与已知在PVN神经元中与GAL共存的儿茶酚胺去甲肾上腺素（NE）协同作用。
