1H-吲哚-4,7-二酮的合成及其抗真菌活性
Synthesis and antifungal activity of 1H-indole-4,7-diones.
作者信息
Ryu Chung-Kyu, Lee Jung Yoon, Park Rae-Eun, Ma Mi-Young, Nho Ji-Hee
机构信息
College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2007 Jan 1;17(1):127-31. doi: 10.1016/j.bmcl.2006.09.076. Epub 2006 Sep 29.
PMID:17046257
Abstract
1H-Indole-4,7-diones were synthesized and tested for in vitro antifungal activity against fungi. The synthesized 1H-indole-4,7-diones generally showed good antifungal activity against Candida krusei, Cryptococcus neoformans, and Aspergillus niger. The results suggest that 1H-indole-4,7-diones would be potent antifungal agents.
摘要
合成了1H-吲哚-4,7-二酮，并对其进行了抗真菌体外活性测试。合成的1H-吲哚-4,7-二酮通常对克鲁斯念珠菌、新型隐球菌和黑曲霉表现出良好的抗真菌活性。结果表明，1H-吲哚-4,7-二酮可能是有效的抗真菌剂。
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