Ryu Chung-Kyu, Lee Jung Yoon, Park Rae-Eun, Ma Mi-Young, Nho Ji-Hee
College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, Republic of Korea.
Bioorg Med Chem Lett. 2007 Jan 1;17(1):127-31. doi: 10.1016/j.bmcl.2006.09.076. Epub 2006 Sep 29.
1H-Indole-4,7-diones were synthesized and tested for in vitro antifungal activity against fungi. The synthesized 1H-indole-4,7-diones generally showed good antifungal activity against Candida krusei, Cryptococcus neoformans, and Aspergillus niger. The results suggest that 1H-indole-4,7-diones would be potent antifungal agents.
合成了1H-吲哚-4,7-二酮，并对其进行了抗真菌体外活性测试。合成的1H-吲哚-4,7-二酮通常对克鲁斯念珠菌、新型隐球菌和黑曲霉表现出良好的抗真菌活性。结果表明，1H-吲哚-4,7-二酮可能是有效的抗真菌剂。
