College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, Republic of Korea.
Bioorg Med Chem Lett. 2011 Jan 1;21(1):427-30. doi: 10.1016/j.bmcl.2010.10.124. Epub 2010 Oct 30.
6-Hydroxy-1H-carbazole-1,4(9H)-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that 6-hydroxy-1H-carbazole-1,4(9H)-diones would be potent antifungal agents.
6-羟基-1H-咔唑-1,4(9H)-二酮被合成并测试了其对两种致病真菌菌株的体外抗真菌活性。在测试的化合物中，许多化合物表现出良好的抗真菌活性。结果表明，6-羟基-1H-咔唑-1,4(9H)-二酮可能是有效的抗真菌剂。
