Flem Elmira, Vainio Kirsti, Døllner Henrik, Midgaard Cathrine, Bosse Franziskus Johannes, Rognlien Anne-Gro Wesenberg, Rojahn Astrid, Nordbo Svein A, Størvold Gunnar, Njølstad Gro, Wathne Karl-Olaf, Konsmo Kirsten, Aavitsland Preben
Division of Infectious Disease Control, Norwegian Institute of Public Health, Nydalen, Oslo, Norway.
Scand J Infect Dis. 2009;41(10):753-9. doi: 10.1080/00365540903161515.
We aimed to evaluate rotavirus morbidity and describe rotavirus epidemiology in hospitalized children in Norway to provide information before the introduction of new rotavirus vaccines. We retrospectively reviewed 14,973 gastroenteritis hospitalizations in children aged <5 y for the period 1995 to 2004, and prospectively surveyed for rotavirus in 311 children aged <5 y admitted with diarrhoea to 3 hospitals in 2006-2008. The proportion of rotavirus among all gastroenteritis hospitalizations was estimated at 14.5% from the retrospective data and at 62.9% in the prospective data. The annual incidence of rotavirus hospitalizations is estimated to be 3 per 1000 children <5 y of age, corresponding to approximately 900 (range 735-1092) hospitalizations each year. Children aged 6-23 months accounted for 61% of all confirmed rotavirus cases, and average duration of hospital stay for rotavirus cases was 1.3 days. We observed a predominance of rotavirus infections from March through May, similar to the seasonality of diarrhoea-associated hospitalizations with viral and unspecified aetiology. No rotavirus-associated deaths were reported. It is estimated that two thirds of all gastroenteritis hospitalizations in children <5 y of age may be attributable to rotavirus in Norway. Continued surveillance and further studies are needed to assess the full burden of rotavirus disease and its economic impact in Norway.
我们旨在评估挪威住院儿童的轮状病毒发病率，并描述轮状病毒流行病学情况，以便在新型轮状病毒疫苗引入之前提供相关信息。我们回顾性分析了1995年至2004年期间14973例5岁以下儿童因胃肠炎住院的病例，并在2006 - 2008年对3家医院收治的311例5岁以下腹泻儿童进行了轮状病毒的前瞻性调查。根据回顾性数据，所有胃肠炎住院病例中轮状病毒的比例估计为14.5%，前瞻性数据中为62.9%。估计5岁以下儿童轮状病毒住院的年发病率为每1000名儿童中有3例，相当于每年约900例（范围735 - 1092例）住院病例。6至23个月大的儿童占所有确诊轮状病毒病例的61%，轮状病毒病例的平均住院时间为1.3天。我们观察到3月至5月轮状病毒感染占主导，这与病毒和病因未明的腹泻相关住院的季节性相似。未报告与轮状病毒相关的死亡病例。据估计，在挪威5岁以下儿童所有胃肠炎住院病例中，约三分之二可能归因于轮状病毒。需要持续监测和进一步研究，以评估挪威轮状病毒疾病的全部负担及其经济影响。
