Kuehn Carrie M, Mueller Beth A, Checkoway Harvey, Williams Marcia
Department of Epidemiology, School of Public Health & Community Medicine, University of Washington, Seattle, WA, USA.
Environ Res. 2007 Mar;103(3):405-12. doi: 10.1016/j.envres.2006.08.008. Epub 2006 Oct 13.
Hazardous waste sites often contain substances harmful to fetal development. Using linked birth-hospital discharge and hazardous sites data for Washington State, we evaluated the association between malformation occurrence and maternal residential proximity to hazardous waste sites. Cases (N=63,006) were infants born 1987-2001 with malformations. Controls (N=315,030) were randomly selected infants without malformations born during these years. Distance between maternal residence and nearest hazardous waste site was measured using geographic information systems (GIS) software. Odds ratio (OR) estimates of the relative risk of malformation at varying distances were calculated. Relative to living >5 miles from a site, living < or = 5 miles was associated with increased risk of any malformations in offspring (for >2- < or = 5 miles: OR 1.15: 95% Confidence Interval (CI): 1.10, 1.21; for >1- < or = 2 miles: OR 1.26, 95% CI: 1.20, 1.32; for >0.5- < or = 1 miles: OR 1.28, 95% CI: 1.22, 1.35; for < or = 0.5 miles: OR 1.33, 95% CI: 1.27, 1.40.) Risk estimates varied by urban vs. rural maternal residence and by specific malformation type. Hazardous waste sites are often located within populated areas. Thus, the possibility of increased malformation occurrence among those in close proximity deserves closer scrutiny.
危险废物场地通常含有对胎儿发育有害的物质。利用华盛顿州出生与医院出院记录以及危险场地数据的关联信息，我们评估了畸形发生率与母亲居住地距危险废物场地的距离之间的关联。病例（N = 63,006）为1987年至2001年出生的患有畸形的婴儿。对照（N = 315,030）为这些年份中随机选取的无畸形婴儿。使用地理信息系统（GIS）软件测量母亲居住地与最近危险废物场地之间的距离。计算了不同距离下畸形相对风险的比值比（OR）估计值。与居住在距离场地超过5英里的情况相比，居住在距离场地小于或等于5英里的范围内与后代出现任何畸形的风险增加相关（对于距离大于2英里至小于或等于5英里的情况：OR 1.15；95%置信区间（CI）：1.10，1.21；对于距离大于1英里至小于或等于2英里的情况：OR 1.26，95% CI：1.20，1.32；对于距离大于0.5英里至小于或等于1英里的情况：OR 1.28，95% CI：1.22，1.35；对于距离小于或等于0.5英里的情况：OR 1.33，95% CI：1.27，1.40）。风险估计因母亲居住在城市还是农村以及特定畸形类型而异。危险废物场地通常位于人口密集地区。因此，居住在附近的人群中畸形发生率增加的可能性值得更密切的审视。
