Mueller Beth A, Kuehn Carrie M, Shapiro-Mendoza Carrie K, Tomashek Kay M
Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.
Environ Health Perspect. 2007 May;115(5):776-80. doi: 10.1289/ehp.9750. Epub 2007 Feb 14.
The in utero period is one of increased susceptibility to environmental effects. The effects of prenatal exposure to environmental toxicants on various adverse pregnancy outcomes, including fetal death, are not well understood.
We examined the risk of fetal death in relation to maternal residential proximity to hazardous waste sites.
We conducted a population-based case-control study using Washington State vital records for 1987-2001. Cases were women with fetal deaths at > or = 20 weeks (n = 7,054). Ten controls per case were randomly selected from live births. Locations of 939 hazardous waste sites were identified from the Department of Ecology registry. We measured distance from maternal residence at delivery to the nearest hazardous waste site, and calculated odds ratios (ORs) and 95% confidence intervals (CIs).
The risk of fetal death for women residing < or = 0.5 miles, relative to > 5 miles, from a hazardous waste site was not increased (adjusted OR = 1.06; 95% CI, 0.90-1.25). No associations were observed for any proximity categories < or = 5 miles from sites with contaminated air, soil, water, solvents, or metals; however, fetal death risk increased among women residing < or = 1 mile from pesticide-containing sites (OR = 1.28; 95% CI, 1.13-1.46).
These results do not suggest that fetal death is associated with residential proximity to hazardous waste sites overall; however, close proximity to pesticide-containing sites may increase the risk of fetal death.
子宫内时期是对环境影响易感性增加的时期之一。产前暴露于环境毒物对包括胎儿死亡在内的各种不良妊娠结局的影响尚不清楚。
我们研究了与母亲居住在危险废物场地附近相关的胎儿死亡风险。
我们利用华盛顿州1987 - 2001年的生命记录进行了一项基于人群的病例对照研究。病例为孕周≥20周的胎儿死亡妇女（n = 7,054）。每个病例随机选取10名活产儿作为对照。从生态部登记处确定了939个危险废物场地的位置。我们测量了分娩时母亲居住地到最近危险废物场地的距离，并计算了比值比（OR）和95%置信区间（CI）。
居住在距离危险废物场地≤0.5英里的妇女与距离>5英里的妇女相比，胎儿死亡风险没有增加（调整后的OR = 1.06；95% CI，0.90 - 1.25）。对于距离受污染空气、土壤、水、溶剂或金属的场地≤5英里的任何邻近类别，均未观察到关联；然而，居住在距离含农药场地≤1英里的妇女中，胎儿死亡风险增加（OR = 1.28；95% CI，1.13 - 1.46）。
这些结果并不表明胎儿死亡总体上与居住在危险废物场地附近有关；然而，靠近含农药场地可能会增加胎儿死亡风险。
