Garg A N, Weginwar R G, Sagdeo V
Department of Chemistry, Nagpur University, India.
Biol Trace Elem Res. 1990 Jul-Dec;26-27:485-96. doi: 10.1007/BF02992704.
Many minor and trace elements influence the permeability of cell membranes by competing for binding sites, and exert direct or indirect action on the carcinogenic process. Instrumental and radiochemical neutron activation analysis has been employed for the determination of more than 20 elements in normal and cancerous breast tissues of 6 patients. Most trace elements, viz., Zn, Cu, Mn, Co, Se, Br, As, Sb and Cd, are elevated in cancerous tissue, whereas lower levels are observed for Fe, Cs, I, and Sr. Similarly, concentrations of minor constituents, such as Na, K, P, Cl, and Mg, are enhanced compared to normal tissue. Several elements incorporate into the normal cell, change its enzymatic activity, and accelerate the growth of tumor.
许多微量元素和痕量元素通过竞争结合位点影响细胞膜的通透性，并对致癌过程产生直接或间接作用。已采用仪器中子活化分析和放射化学中子活化分析来测定6例患者正常乳腺组织和癌组织中的20多种元素。大多数微量元素，即锌、铜、锰、钴、硒、溴、砷、锑和镉，在癌组织中含量升高，而铁、铯、碘和锶的含量则较低。同样，与正常组织相比，钠、钾、磷、氯和镁等次要成分的浓度也有所增加。几种元素进入正常细胞，改变其酶活性，并加速肿瘤生长。
