An Lei, Tang Jin-tian, Liu Xin-min, Gao Nan-nan
Institute of Medicinal Plant Devlopment, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Zhongguo Zhong Yao Za Zhi. 2006 Aug;31(15):1225-6, 1260.
This paper gave a brief introduction of the effect of Solanum nigrum on anti-cancer. The experimental results showed that the total alkaloid isolated from S. nigrum interfered structure and function of tumor cell membrane, disturbed the synthesis of DNA and RNA, changed the cell cycle distribution, so that total alkaloids could play in inhibabition to tumor cells, while the glycoprotein (150 x 10(3)) isolated from S. nigrum might have shown anti-cancer abilities by blocking the anti-apoptotic pathway of NF-kappaB, activating caspase cascades reaction and increasing the production of nitric oxide.
本文简要介绍了龙葵的抗癌作用。实验结果表明，从龙葵中分离得到的总生物碱可干扰肿瘤细胞膜的结构和功能，扰乱DNA和RNA的合成，改变细胞周期分布，从而对肿瘤细胞发挥抑制作用，而从龙葵中分离得到的糖蛋白（150×10³）可能通过阻断NF-κB的抗凋亡途径、激活半胱天冬酶级联反应并增加一氧化氮的产生而显示出抗癌能力。
