转录后三重调控。

Triple post-transcriptional control.

作者信息

Bechhofer D H

机构信息

Department of Biochemistry, Mount Sinai School of Medicine, New York, New York 10029.

出版信息

Mol Microbiol. 1990 Sep;4(9):1419-23. doi: 10.1111/j.1365-2958.1990.tb02051.x.

DOI:10.1111/j.1365-2958.1990.tb02051.x

PMID:1704997

Abstract

The ermC gene confers resistance to MLS antibiotics in a Bacillus subtilis host. Synthesis of the ermC gene product, a ribosomal RNA methylase, is inducible by the addition of subinhibitory concentrations of erythromycin. Regulation of ermC gene expression occurs at the post-transcriptional level in three ways: translational attenuation, translational autoregulation, and messenger RNA stabilization.

摘要

ermC基因赋予枯草芽孢杆菌宿主对MLS抗生素的抗性。ermC基因产物（一种核糖体RNA甲基化酶）的合成可通过添加亚抑制浓度的红霉素来诱导。ermC基因表达的调控在转录后水平以三种方式发生：翻译弱化、翻译自调控和信使RNA稳定化。