Doi K, Okawa H, Sakuma S, Okaniwa A
Natl Inst Anim Health Q (Tokyo). 1975 Summer;15(2):76-85.
Histopathological observations were carried out on 17 domestic cats naturally affected with feline panleukopenia. Principal lesions were found in the intestine, bone marrow, and lymphoid organs. Intestinal lesions were characterized by degenerative changes accompanied by the appearance of intranuclear inclusion bodies in the epithelial cells of the crypts. In contrast to the crypts, the villi were seldom involved. Hypoplasia, parenchymal degeneration, and activation of the reticuloendothelial system were observed in the bone marrow and lymphoid organs. Intranuclear inclusion bodies were found occasionally also in the reticular and parenchymal cells of the bone marrow, lymphoid organs, liver, adrenals, and pancreas. Most of the inclusion bodies were amphophilic when stained with hematoxylin and eosin and occupied the whole area of the nucleus without producing any zone of clear halo. While cells bearing inclusion bodies underwent degenerative changes constantly in the intestinal crypts, the formation of inclusion body was not accompanied by the degeneration of corresponding cells in any other organ. Pathological changes as mentioned above were considered to be closely related to the systemic infection of feline panleukopenia virus.
对17只自然感染猫泛白细胞减少症的家猫进行了组织病理学观察。主要病变见于肠道、骨髓和淋巴器官。肠道病变的特征为变性改变，同时隐窝上皮细胞内出现核内包涵体。与隐窝不同，绒毛很少受累。骨髓和淋巴器官可见发育不全、实质变性以及网状内皮系统激活。骨髓、淋巴器官、肝脏、肾上腺和胰腺的网状细胞和实质细胞中偶尔也发现核内包涵体。大多数包涵体用苏木精和伊红染色时呈嗜双色性，占据整个细胞核区域，不产生任何透明晕圈。虽然带有包涵体的细胞在肠道隐窝中不断发生变性改变，但在任何其他器官中，包涵体的形成都不伴有相应细胞的变性。上述病理变化被认为与猫泛白细胞减少症病毒的全身感染密切相关。
