Korfias Stefanos, Stranjalis George, Psachoulia Christina, Vasiliadis Constantinos, Pitaridis Marinos, Boviatsis Efstathios, Sakas Damianos E
Department of Neurosurgery, University of Athens, Evangelismos Hospital, Athens, Greece.
Brain Inj. 2006 Jul;20(8):867-72. doi: 10.1080/02699050600832395.
Serum S-100B protein is an established biochemical marker of traumatic brain injury. At the same time, the question of extra-cranial S-100B release has been raised. This study evaluates the post-traumatic and post-operative release kinetics of S-100B in 45 trauma victims without head injury.
Serum S-100B protein was measured on admission and every 24 hours for 4 consecutive days.
Initial S-100B was slightly increased (median: 0.54 microg L-1) and correlated with the severity of extra-cranial trauma (p = 0.0004, Mann-Whitney test). Both severely (abdominal or chest trauma with or without bone fractures) and mildly (long bone fractures) injured showed a rapid decline of S-100B (< 0.2 microg L-1) around 72 hours post-trauma. Extra-cranial surgery caused a secondary increase of S-100B, especially in the mildly injured group (p = 0.004, Wilcoxon signed rank test).
Extra-cranial injury results in a mild elevation of serum S-100B protein that declines rapidly (1-3 days after injury).
血清S-100B蛋白是创伤性脑损伤公认的生化标志物。同时，颅外S-100B释放的问题也已被提出。本研究评估了45例无头部损伤的创伤患者创伤后及术后S-100B的释放动力学。
入院时及连续4天每天测量血清S-100B蛋白。
初始S-100B略有升高（中位数：0.54微克/升），与颅外创伤的严重程度相关（p = 0.0004，曼-惠特尼检验）。重度（伴有或不伴有骨折的腹部或胸部创伤）和轻度（长骨骨折）受伤患者在创伤后约72小时均出现S-100B快速下降（<0.2微克/升）。颅外手术导致S-100B再次升高，尤其是在轻度受伤组（p = 0.004，威尔科克森符号秩检验）。
颅外损伤导致血清S-100B蛋白轻度升高，并迅速下降（受伤后1 - 3天）。
