在选择标签单核苷酸多态性（tag SNPs）时结合功能和连锁不平衡信息。

Combining functional and linkage disequilibrium information in the selection of tag SNPs.

作者信息

Sham P C, Ao S I, Kwan J S H, Kao P, Cheung F, Fong P Y, Ng M K

机构信息

Department of Psychiatry, Institute of Psychiatry, King's College London, UK.

出版信息

Bioinformatics. 2007 Jan 1;23(1):129-31. doi: 10.1093/bioinformatics/btl532. Epub 2006 Oct 23.

DOI:10.1093/bioinformatics/btl532

PMID:17060359

Abstract

UNLABELLED

We have developed an online program, WCLUSTAG, for tag SNP selection that allows the user to specify variable tagging thresholds for different SNPs. Tag SNPs are selected such that a SNP with user-specified tagging threshold C will have a minimum R2 of C with at least one tag SNP. This flexible feature is useful for researchers who wish to prioritize genomic regions or SNPs in an association study.

AVAILABILITY

The online WCLUSTAG program is available at http://bioinfo.hku.hk/wclustag/

摘要

未标注

我们开发了一个在线程序WCLUSTAG用于标签单核苷酸多态性（SNP）选择，该程序允许用户为不同的SNP指定可变的标签阈值。选择标签SNP的方式是，具有用户指定标签阈值C的SNP与至少一个标签SNP的最小R2为C。这种灵活的特性对于希望在关联研究中对基因组区域或SNP进行优先级排序的研究人员很有用。