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青蒿素四种新衍生物对刚地弓形虫的体外抑制作用

In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin.

作者信息

Jones-Brando Lorraine, D'Angelo John, Posner Gary H, Yolken Robert

机构信息

Stanley Division of Developmental Neurovirology, Dept. of Pediatrics, Johns Hopkins University School of Medicine, 600 N. Wolfe St., Baltimore, MD 21287-4988, USA.

出版信息

Antimicrob Agents Chemother. 2006 Dec;50(12):4206-8. doi: 10.1128/AAC.00793-06. Epub 2006 Oct 23.

DOI:10.1128/AAC.00793-06
PMID:17060514
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1693994/
Abstract

Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is medically important and distributed worldwide. Currently available medications are limited in terms of efficacy and side effects. We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture.

摘要

弓形虫病由原生动物刚地弓形虫引起，在医学上具有重要意义，且分布于全球。目前可用的药物在疗效和副作用方面存在局限性。我们合成了新型的、非缩醛的、水解稳定的青蒿素衍生物，并表明它们在细胞培养中能抑制刚地弓形虫的复制。

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本文引用的文献

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Psychopathology in first-episode schizophrenia and antibodies to Toxoplasma gondii.首发精神分裂症的精神病理学与弓形虫抗体
Psychopathology. 2005 Mar-Apr;38(2):87-90. doi: 10.1159/000085349. Epub 2005 Apr 22.
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A medicinal chemistry perspective on artemisinin and related endoperoxides.从药物化学角度看青蒿素及相关内过氧化物。
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Drugs used in the treatment of schizophrenia and bipolar disorder inhibit the replication of Toxoplasma gondii.用于治疗精神分裂症和双相情感障碍的药物可抑制弓形虫的复制。
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Antibodies to Toxoplasma gondii in individuals with first-episode schizophrenia.首发精神分裂症患者体内抗弓形虫抗体情况
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Toxoplasma gondii: from animals to humans.弓形虫：从动物到人类
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In vitro effects of artemisinin ether, cycloguanil hydrochloride (alone and in combination with sulfadiazine), quinine sulfate, mefloquine, primaquine phosphate, trifluoperazine hydrochloride, and verapamil on Toxoplasma gondii.青蒿素醚、盐酸环氯胍（单独及与磺胺嘧啶联用）、硫酸奎宁、甲氟喹、磷酸伯氨喹、盐酸三氟拉嗪及维拉帕米对刚地弓形虫的体外作用
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Management of toxoplasmosis.弓形虫病的管理。
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